Monday, 18 May 2026

The Evolution of Cannabis: 28 Million Years of Secrets Hidden From You

Mysteries of the World, Apr 26, 2026

(Use the link to watch on ytube for english, Chuck)

About 28 million years ago, a small plant emerged on the slopes of the ancient Tibetan Plateau that was destined to change the course of human history.

 Cannabis is one of the most mysterious and controversial plants on Earth, and its evolutionary history is far more astonishing than you might imagine.

 In this video, we'll explore the complete evolution of cannabis: from its origins in the high steppes of Asia to its emergence as a companion plant 12,000 years ago—long before wheat, corn, and potatoes. You'll learn how plate tectonics literally created the conditions for this plant's emergence, why cannabis and hops (the basis of beer brewing) turned out to be genetically related, and how a groundbreaking 2021 study involving whole-genome sequencing has revolutionized scientists' understanding of marijuana's origins. 

But the most intriguing question is: why is cannabis capable of altering our consciousness? The answer lies in the endocannabinoid system, an ancient biological network that has existed in animals for 600 million years—we even share it with sea urchins.

A plant that evolved to protect itself from UV rays and herbivores accidentally created a molecule that perfectly fits receptors in our brain. We'll talk about the Scythians and Herodotus, ancient rituals in the Chinese mountains, the secret breeding of cannabis in 20th-century basements, and how humans turned the plant's defense mechanism into a source of pleasure. 

This is a story about how geology shapes biology, and biology shapes culture. 

go to above link for english version


The Life of Earth
https://chuckincardinal.blogspot.com/







Common Cleaning Chemical Could Triple Your Risk of a Dangerous Liver Disease

By SciTechDaily.com, May 18, 2026

Liver fibrosis is a condition in which excessive scar tissue builds up in the liver after repeated injury or inflammation. Over time, this scarring can disrupt normal liver function and may progress to cirrhosis, liver failure, or liver cancer if left untreated. 
Credit: Stock

Scientists are uncovering a possible connection between everyday chemical exposure and serious liver damage.

Most people associate liver disease with heavy drinking or obesity. But researchers are increasingly uncovering another possible threat hiding in everyday life: industrial chemicals that can linger in the air we breathe, the water we drink, and even the clothes we pick up from the dry cleaner.

A new study published in Liver International points to tetrachloroethylene (PCE), a chemical widely used in dry cleaning and manufacturing, as a potential contributor to serious liver damage. Scientists at Keck Medicine of USC found that people with detectable levels of PCE in their blood were more than three times as likely to have significant liver fibrosis, a dangerous buildup of scar tissue that can eventually lead to liver failure, liver cancer, or death.


Tetrachloroethylene (PCE), widely used in dry cleaning and manufacturing, has been linked to increased odds of liver scarring. Credit: Stock



The findings add to growing concerns about how environmental pollutants may quietly influence chronic diseases that are often blamed on lifestyle factors alone. Researchers say the study is the first to directly connect PCE exposure in the general U.S. population with measurable liver scarring.

“This study, the first to examine the association between PCE levels in humans and significant liver fibrosis, underscores the underreported role environmental factors may play in liver health,” said Brian P. Lee, MD, MAS, a hepatologist and liver transplant specialist with Keck Medicine and lead author of the study. “The findings suggest that exposure to PCE may be the reason why one person develops liver disease while someone with the exact same health and demographic profile does not.”


Dr. Brian P. Lee, MD, MAS, is a hepatologist and liver transplant specialist with Keck Medicine of USC and principal investigator of the study. Credit: Dr. Brian P. Lee, MD, MAS



A Chemical Found Far Beyond Dry Cleaning

PCE, also called perchloroethylene, is a colorless volatile organic compound used to dissolve grease and remove stains. Although it is best known as a dry-cleaning solvent, it has also been used in metal degreasing, industrial manufacturing, adhesives, spot removers, and some household cleaning products.

Exposure often happens through inhalation. Clothes cleaned with PCE can slowly release the chemical into indoor air for days after pickup. In some communities, the chemical has also contaminated groundwater and drinking water after industrial spills or improper disposal seeped into the soil. Because PCE evaporates easily, it can spread through buildings and surrounding neighborhoods as a vapor.

Scientists have studied PCE for decades because of its toxic effects. The International Agency for Research on Cancer classifies it as a probable carcinogen, and previous research has linked it to bladder cancer, multiple myeloma, non-Hodgkin lymphoma, and liver cancer. Animal studies have also shown that the chemical can trigger inflammation, oxidative stress, and cellular damage in the liver.

In response to mounting evidence, the U.S. Environmental Protection Agency recently began a 10-year phaseout of PCE in dry cleaning operations and imposed new restrictions on several industrial uses. Still, the compound remains present in some workplaces, consumer products, and older contaminated sites.

Tracking Liver Damage in the U.S. Population

To investigate whether PCE exposure might be affecting liver health on a national scale, researchers analyzed data from the National Health and Nutrition Examination Survey (NHANES), a long-running federal program designed to reflect the health of the U.S. population.

The study included 1,614 adults age 20 and older between 2017 and 2020. Blood testing showed that about 7.4% of participants had detectable levels of PCE. Concentrations ranged from 0.034 to 57.5 nanograms per milliliter.

After adjusting for age, sex, race, ethnicity, education, and other health factors, the connection between PCE and liver fibrosis remained strong. People with detectable PCE exposure had more than triple the odds of significant liver fibrosis compared with those who had no detectable exposure.


PCE can contaminate air and groundwater, creating potential exposure far beyond dry-cleaning shops.
 Credit: Stock



The study also found a striking dose-response relationship: for every one nanogram per milliliter increase in blood PCE concentration (one nanogram is one-billionth of a gram), the odds of significant liver fibrosis increased more than fivefold, with detectable PCE exposure corresponding to an absolute increase in fibrosis risk of nearly 28%.

Importantly, the association appeared independent of traditional liver disease risks such as alcohol use or obesity-related fatty liver disease. That finding raises the possibility that environmental toxins may help explain why some people develop liver disease despite having few conventional risk factors.

“Patients will ask, how can I have liver disease if I don’t drink and I don’t have any of the health conditions typically associated with liver disease, and the answer may be PCE exposure,” said Lee.
Who Faces the Highest Exposure?

The study found that people from higher-income households were more likely to have detectable PCE levels, possibly because they use dry-cleaning services more frequently. However, researchers noted that workers in dry-cleaning facilities and industrial settings may face even greater exposure because of repeated, direct contact with the chemical over long periods.

The authors also performed a “negative control” analysis using a different biomarker linked to mixed VOC exposure. That analysis suggested the liver fibrosis signal was specifically tied to PCE rather than to volatile chemicals in general, strengthening confidence in the findings.
A Growing Focus on Environmental Liver Disease

Liver disease is becoming more common worldwide, and researchers are increasingly exploring how pollution and chemical exposure may contribute alongside diet and alcohol. Unlike smoking or obesity, environmental exposures are often invisible and difficult for individuals to control. Some chemicals can accumulate slowly over years before symptoms appear.

Lee believes the new findings should encourage more research into how environmental toxins affect the liver and whether earlier screening could help identify damage before it becomes irreversible.

“No doubt there are other toxins in our environment besides PCE that are dangerous to the liver,” he said.

He added that recognizing these hidden risk factors could eventually improve patient outcomes.

“We hope our research will help both the public and physicians understand the connection between PCE exposure and significant liver fibrosis,” Lee said. “If more people with PCE exposure are screened for liver fibrosis, the disease can be caught earlier and patients may have a better chance of recovering their liver function.”


The Life of Earth
https://chuckincardinal.blogspot.com/

Scientists Discover “Good” Gut Microbes That Could Protect Against Autism and ADHD

By Cell Press, May 17, 2026

A new study suggests that the gut microbiome and epigenetic “switches” that regulate genes may work together from birth to shape early brain development. 
Credit: Stock

A study found that early-life epigenetic changes and gut microbiome development are closely linked and may shape the risk of ASD and ADHD. Some gut bacteria appeared to offer protective effects against these conditions.

From the moment a baby is born, trillions of microbes begin colonizing the gut while molecular “switches” in the body help control which genes are active.

Now, researchers have found that these two systems, the gut microbiome and epigenetics, may work together in ways that influence early brain development and could shape the risk of neurodevelopmental conditions later in childhood.

The study, published in the journal Cell Press Blue, showed that epigenetic changes present at birth can affect how an infant’s gut microbiome develops during the first year of life. The researchers also identified specific epigenetic patterns and gut microbes linked to signs of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) at age three. Some microbes even appeared to play a protective role, potentially reducing the effects associated with certain epigenetic risk patterns.

“Certain bacteria seem to offer protection, which is exciting because it suggests there could be ways to support a child’s development through diet or probiotics in the future,” says senior author and gastroenterologist Francis Ka Leung Chan of The Chinese University of Hong Kong.

Early childhood is a critical period for both brain development and immune system maturation. While previous studies have shown that epigenetic changes and the infant gut microbiome can each influence long-term health, far less is known about how the two systems interact during the earliest stages of life.

Early-Life Epigenome and Microbiome Interaction

“We wanted to see how the epigenome and microbiome interact in early life and if their interaction could influence a child’s risk of developing neurodevelopmental conditions like ASD and ADHD,” says co-senior author and public health researcher Hein Min Tun of The Chinese University of Hong Kong. “We discovered a kind of conversation happening: a baby’s epigenetic setting at birth can influence their risk for neurodevelopmental disorders, but the presence of certain ‘good’ bacteria in their gut can step in and modify the risk.”

The researchers analyzed DNA methylation patterns, a form of epigenetic change, using umbilical cord blood samples from 571 infants. They combined these findings with gut microbiome data collected from 969 infants at 2, 6, and 12 months of age, as well as samples from the parents during the third trimester of pregnancy.

When the children reached 36 months of age, the team used behavioral questionnaires to evaluate neurodevelopment and explore possible connections between the microbiome, epigenome, and early signs of ASD and ADHD.

The results showed that an infant’s epigenome at birth was linked to factors such as delivery method, gestation length, maternal allergies, and having older siblings. However, it was not influenced by the parents’ gut microbiomes. In contrast, microbiome development was associated with delivery method, antibiotic exposure, breastfeeding, and older siblings. Babies delivered by Cesarean section showed different DNA methylation patterns in genes involved in immune function and brain development.
DNA Methylation Linked to Gut Microbiome Diversity

The researchers also found that epigenetic patterns present at birth affected how the microbiome developed during the first year of life. Infants with higher DNA methylation levels in immune genes related to pathogen recognition tended to have less diverse gut microbiomes by 12 months of age.

The behavioral assessments further showed that signs of ASD and ADHD in 3-year-old children were connected to specific epigenetic markers and certain gut microbes.

Some microbial species appeared to reduce these effects. Infants with epigenetic patterns linked to ASD or ADHD were less likely to show signs of the conditions if they acquired Lachnospira pectinoschiza and Parabacteroides distasonis, respectively, during their first year.

Probiotics and Early Interventions for Neurodevelopment

“The foundations for brain health are laid very early, even before birth,” says Tun. “However, we don’t want people to think this means a child’s developmental path is fixed at birth. These are complex conditions with many causes, and we’ve only uncovered a small piece of a very large puzzle.”

The researchers are continuing to track the children involved in the study to better understand how these early-life factors may influence health later on. They also note that laboratory studies are still needed to confirm the relationship between gut microbes and neurodevelopment.

“The ultimate goal is to develop safe, non-intrusive early interventions such as specific probiotics or live biotherapeutics, that could help nurture a healthy gut microbiome and potentially reduce the risk of neurodevelopmental challenges,” says first author and gastroenterologist Siew Chien Ng of The Chinese University of Hong Kong.


The Life of Earth
https://chuckincardinal.blogspot.com/

Sunday, 17 May 2026

Chuck's picture corner to May 17, 2026

Babies are abounding in the yard, we are finally going to get 3 whole days of above average temps before they once again drop below average for at least a week and who knows beyond that. Fruit trees are beginning to bloom and most shrubs and trees are leafing out. I cut the lawn last week and the next morning had my first signs of allergy symptoms. Ahhh the winter air has also come alive.

the pear tree in bloom behind the cherry tree in bloom taken this morning

 the side yard looking green and alive

I visited Rachelle yesterday, and she has lots of birds visiting her feeders.

A rose breasted grosbeak and I haven't identified the bird on the right.

a purple leafed purple flowering crab, birds enjoy the berries later in the year.

plum blossoms

plum in bloom

I'm putting steel siding up on the house, 10' sheets vertically of black and mid grey in a checkerboard pattern.

what I can reach on the ladder, I'll be putting scaffolding up and have asked for help from the lads the first weekend of July. (any other volunteers would be welcome)

the end of another day.

the first house project of the season begins.

not sure what this weed is.

the white liloc beginning to bloom

It's hard for me to believe I planted these golden weeping willows as cutting a couple of dozen years ago

the clouds of spring

viola

driving home from the grocery store, down the hill on a street facing the river


Enjoy the day
https://chuckincardinal.blogspot.com/

Beyond Pain Relief: Scientists Discover a Protein That Could Stop Osteoarthritis in Its Tracks

By National Research Council of Sci. & Tech., May 16, 2026

Researchers have identified a protein that appears to play a crucial role in protecting cartilage from the damage associated with osteoarthritis, a leading cause of joint pain and reduced mobility worldwide. 
Credit: Stock

Researchers have identified the SHP protein as a key regulator that suppresses cartilage-degrading enzymes and slows osteoarthritis progression.

For millions of people living with osteoarthritis, treatment options have long focused on one thing: managing pain. But while medications and injections may temporarily ease aching knees and stiff fingers, they do little to stop the slow destruction of cartilage that lies at the heart of the disease.

Now, scientists in South Korea say they may have uncovered a powerful new way to protect joints before the damage becomes irreversible.

In a new study published in Nature Communications, researchers identified a protein called SHP (NR0B2) that appears to act as a natural defender of cartilage. The team found that SHP levels decline as osteoarthritis progresses, accelerating joint deterioration. Restoring the protein in animal models not only reduced cartilage damage but also improved joint function and eased pain, raising hopes for therapies that could one day slow or even halt the disease itself.

The research was led by Dr. Chul-Ho Lee and Dr. Yong-Hoon Kim at the Laboratory Animal Resource Center of the Korea Research Institute of Bioscience and Biotechnology (KRIBB), in collaboration with Prof. JinHyun Kim at Chungnam National University Hospital.


From left: Kang Eun-jeong, researcher, and Lee Chul-ho and Kim Yong-hoon, principal researchers at KRIBB. 
Credit: KRIBB



SHP protects vulnerable cartilage

To investigate SHP’s role, the researchers analyzed cartilage tissue from osteoarthritis patients as well as animal models of the disease. They discovered that SHP protein levels dropped sharply as osteoarthritis advanced, suggesting that the loss of this protective molecule may contribute directly to cartilage breakdown.

Further experiments revealed just how important the protein may be. Mice lacking SHP developed more severe pain and experienced faster cartilage degeneration than normal mice. In contrast, restoring SHP levels in affected joints significantly reduced cartilage damage and improved mobility, highlighting the protein’s potential as a therapeutic target.
A pathway slows cartilage breakdown

The mechanistic work showed that SHP helps defend cartilage by reducing the production of enzymes that destroy the tissue, especially MMP-3 and MMP-13.

These enzymes are known to break down cartilage. For the first time, the researchers showed that SHP blocks these enzymes at the signaling level by controlling the IKKβ/NF-κB pathway, helping preserve cartilage structure.

Schematic illustration of SHP (NR0B2)-mediated protection against osteoarthritis.
 Credit: Korea Research Institute of Bioscience and Biotechnology (KRIBB)

Gene delivery reduces damage

The team then tested whether SHP could be used therapeutically through gene delivery. After injecting a viral vector carrying the SHP gene into affected joints, the researchers observed lasting benefits from a single treatment.

Even in animals that already had osteoarthritis, the approach significantly reduced cartilage damage and relieved pain.

“This study is the first to demonstrate that the SHP protein plays a critical role in protecting cartilage during the development and progression of osteoarthritis,” said Dr. Chul-Ho Lee, the study’s lead investigator. “Therapeutic strategies targeting SHP may offer a new approach to slowing or preventing osteoarthritis progression.”


The Life of Earth
https://chuckincardinal.blogspot.com/

Ancient Roman Technique Discovered 8,000 Years Earlier, Study Says

17 May 2026, By R. McLendon

Interior of the Pantheon, Rome.
 (Francesco Riccardo Iacomino/Moment/Getty Images)

The Roman Empire helped transform humanity for centuries during its reign, then left a legacy that has continued to influence civilization ever since.

Even the ancient Romans had to stand on giants' shoulders, though.

That includes not just earlier civilizations like Egypt and Greece, but also countless prehistoric people whose innovations have been largely lost to history – or, in some cases, erroneously attributed to later generations.

In a new study, researchers report that a sophisticated plaster-making technique long credited to the Romans was also used by Neolithic people about 8,000 years earlier.

But how is that possible?

Ancient Rome is renowned for its engineering prowess, as seen in iconic projects like the aqueducts and the Pantheon. In addition to their design and construction skills, Roman builders likely benefitted from durable concrete and other high-quality materials.

Some Roman buildings incorporated dolomite-based plaster, a quick-drying paste, which is stronger and more water-resistant than the traditional calcitic plasters often produced in antiquity.

"However, using dolomitic lime is challenging and requires a high level of expertise at all steps of preparation, which may explain why it is not commonly found in archaeological sites," the researchers write.

Dolomite refers to a mineral made of calcium magnesium carbonate, or to a rock featuring mostly this mineral. Similar to calcitic limestone, it can serve as a source of the inorganic material lime, which in turn can be useful in the production of certain building materials.

The earliest written record of dolomitic lime seems to come from the Roman architect and engineer Vitruvius during the first century BCE, the authors note.

While Vitruvius didn't mention dolomite by name, he seemed to describe the mineral in a discussion of lime production.

Plaster had been common for a long time before Vitruvius, but there is little indication of anyone using dolomitic lime before his description of it about 2,000 years ago.

Archaeological evidence suggests the main materials for making plaster in prehistory were calcite and gypsum.

About 10,000 years ago, however, people at a Neolithic settlement in the Judean Hills apparently made dolomite-based plaster, leaving behind subtle clues that went unnoticed until now, the researchers report.

Located in what's now Israel and Palestine, this region was already a hub of human activity at the time, bustling with settlements thousands of years before the dawn of the Iron Age or the Roman Empire.

An overview of the Motza archaeological site.
 (Maor et al., J. Archaeol. Sci., 2026)

One of those settlements eventually became the modern-day archaeological site known as Motza, located about 5 kilometers west of Jerusalem, where researchers conducted a series of excavations between 2015 and 2021 before construction of a highway through the area.

Sifting through multiple occupations over the millennia, the researchers focused on a large Neolithic settlement dated to roughly 9,000 years ago. They found more than 100 plaster floors from that era, noting many were "particularly well-preserved and coated with red pigment".

They also found separate kilns where residents had burned either limestone or dolomite to make plaster, indicating a degree of sophistication not often attributed to Neolithic people.

Calcitic and dolomitic lime require different conditions for plaster production, the researchers explain, and yet these prehistoric people evidently understood that well enough to build specialized kilns for each substance.

Using dolomite to make plaster was an impressive feat for humans at the time, but the method employed at Motza remains intriguing even by modern standards, the researchers add.

"They may have successfully made dolomitic plaster where dolomite is fully recrystallized along with the calcite, something that to our knowledge has not been observed anywhere else and was thought to be physically impossible," they write.

Aside from capitalizing on a local abundance of dolomite, this method likely yielded a superior plaster for use in buildings, with greater strength and water resistance than traditional alternatives.

Given the difficulty of making dolomite-based plaster, plus the lack of earlier evidence, credit for its invention has long fallen to Ancient Rome.

While it's possible the technique survived for 8,000 years after Motza and then resurfaced in Rome, the lack of archaeological evidence from the interim seems to indicate the Romans independently discovered it.

"The results suggest a technology lost to history," the researchers write.


The birth of modern Man
https://chuckincardinal.blogspot.com/

Saturday, 16 May 2026

Mysterious Wall Stone Turned Out to Be an Unexpected Treasure

16 May 2026, By M. Starr

You don't see that every day. 
(Hart et al., J. Vertebr. Paleontol., 2023)

It all started with a simple landscaping project.

Retired chicken farmer Mihail Mihailidis just wanted to build a retaining wall. He acquired a block of sandstone from a local quarry in Kincumber, Australia, and set to work preparing it for its new purpose.

When he turned the stone over, however, his plans fell apart.

There, clear as daylight, was an unmistakable impression of an ancient creature. The outline was so distinct that even a non-expert could tell it wasn't just an odd pattern in the rock. Something had been preserved there – something with a spine, limbs, and a body that had once moved through water.


Meet Arenaerpeton supinatus, a name that means "upside-down sand-creeper".
 (UNSW Sydney/Richard Freeman)



In 2023, decades after the Mihailidis family donated the stone to the Australian Museum, scientists formally described the beastie, named Arenaerpeton supinatus. It's a rare, extinct relative of modern amphibians, belonging to a group known as temnospondyls, and it lived hundreds of millions of years ago.

It's similar to a prehistoric salamander, but chunkier, and with a nastier set of teeth.

"Superficially, Arenaerpeton looks a lot like the modern Chinese Giant Salamander, especially in the shape of its head," said paleontologist Lachlan Hart of the University of New South Wales (UNSW) and the Australian Museum.

"However, from the size of the ribs and the soft tissue outline preserved on the fossil, we can see that it was considerably more heavyset than its living descendants. It also had some pretty gnarly teeth, including a pair of fang-like tusks on the roof of its mouth."


An artist's impression of Arenaerpeton in life. 
(Jose Vitor Silva)



The fossil truly is a spectacular specimen. It's preserved in sandstone, which is interesting enough.

Sandstone often preserves ancient traces, but it typically forms in dynamic, oxygen-rich environments where bodies are easily broken apart and decompose quickly.

In most cases, that means only fragments, such as isolated bones, teeth, or tracks, survive long enough to fossilize. Complete skeletons are much harder to come by, and delicate features like skin or body outlines almost never make it through the process intact.

Arenaerpeton – the only specimen of its species ever found – is very far from the typical sandstone fossil. The skeleton is almost complete and fully articulated, and the fossil retains traces of soft tissue – rare in any fossil, let alone sandstone.


The fossil (A) and a diagram (B) of the articulated skeleton of Arenaerpeton.
 (Hart et al., J. Vertebr. Paleontol., 2023)



"This is one of the most important fossils found in New South Wales in the past 30 years, so it is exciting to formally describe it," said paleontologist Matthew McCurry of UNSW and the Australian Museum.

"It represents a key part of Australia's fossil heritage."

The researchers believe that Arenaerpeton died in a calm aquatic environment with anoxic or colder bottom waters, inhospitable to scavengers, where its carcass could lie undisturbed while fossilization processes unfolded.

With little disruption and limited oxygen, decay slowed to a crawl, giving the surrounding sediment time to seal in the shape of the animal's body before it could disintegrate.


Arenaerpeton's cranium and mandible. 
(Hart et al., J. Vertebr. Paleontol., 2023)



"We don't often find skeletons with the head and body still attached," Hart said, "and the soft tissue preservation is an even rarer occurrence."

The animal dates back around 240 million years, to the Triassic period – a time before dinosaurs rose to dominance, when the world was still recovering from the Great Dying, the most devastating extinction event the world has ever seen.

During this time, Australia was still part of the Gondwana supercontinent and sat closer to the South Pole than it does today. Temnospondyls were relatively widespread across Gondwana, and their remains have been found across multiple continents that later split apart.

Arenaerpeton inhabited freshwater rivers in a region now known as the Sydney Basin and likely hunted fish with its fearsome tusks.

The specimen is missing its tail, but Hart estimates its full length was around 1.2 meters (3.9 feet). That's toward the larger end for early temnospondyls in Australia, although some later relatives would grow significantly bigger.

This size could have given it a leg up the evolutionary ladder.

"The last of the temnospondyls were in Australia 120 million years after Arenaerpeton, and some grew to massive sizes," Hart explained.

"The fossil record of temnospondyls spans across two mass extinction events, so perhaps this evolution of increased size aided in their longevity."

Arenaerpeton spent decades languishing in storage before arriving at its rightful place in the fossil record – a missing link that may help explain the rise of the temnospondyls.

So maybe take a leaf out of Mihailidis's book and give a closer look to that slab of rock before adding it to your garden wall.


The Life of Earth
https://chuckincardinal.blogspot.com/

Scientists Say Cognitive Decline Isn’t Inevitable — Your Brain Can Improve at Any Age

By Center for BrainHealth, May 15, 2026

A sweeping new study suggests the human brain may remain capable of meaningful improvement well into old age.
 Credit: Shutterstock

A long-term study found that brain health can improve throughout life with consistent daily habits, cognitive training, and personalized support, regardless of age.

What if the brain doesn’t have to follow the familiar path of gradual decline with age? A major new study published in Scientific Reports is challenging long-held assumptions about aging, revealing that the human brain may remain capable of measurable growth and improvement well into later life.

Researchers at the Center for BrainHealth at The University of Texas at Dallas tracked nearly 4,000 adults between the ages of 19 and 94 over a three-year period. Using the BrainHealth Index (BHI) — a multidimensional tool designed to assess overall brain fitness — the team found that targeted, brain-healthy habits were linked to gains in cognitive performance across the lifespan.

Unlike conventional assessments focused mainly on detecting disease or impairment, the BHI measures growth potential in three key areas: clarity (thinking skills), connectedness (social purpose), and emotional balance (mental resilience).

Key findings

No Limit to Improvement: Participants across all performance levels showed measurable gains in brain health. Even individuals with the highest initial scores continued improving over more than 1,000 days, suggesting brain optimization may not have a clear upper limit.

Biggest Gains Among Low Starters: People who began the study with the lowest baseline scores experienced the fastest and most significant improvement, indicating that poor brain health can be improved over time.

Small Daily Habits Matter: The strongest results were linked to consistency. Participants who spent 5 to 15 minutes per day on microtraining exercises and incorporated brain-healthy habits into daily life achieved the highest scores.

Benefits Across All Ages: Younger adults improved at rates similar to participants in their 70s and 80s, challenging the idea that proactive brain care only benefits older adults.

Case #1 graph from the paper “Measuring and Increasing the Brain Health Span across Adulthood: A Public Health Imperative” shows the trajectory of a male in his 60s with a bachelor’s degree. Employed full time, he also serves as a caregiver for a family member with dementia.
 Credit: Center for BrainHealth

Study Challenges Myths About Cognitive Decline

“For too long, we’ve operated under the outdated notion that we need to wait until something bad happens to our brain before we do anything for it,” said Sandra Bond Chapman, PhD, chief director of the Center for BrainHealth and distinguished professor at UT Dallas.

“This study reminds us that our brain is not defined by age; it is defined by possibility. Humans have already expanded how long we live. Now, we are expanding how long the brain can continue to improve, disrupting the trajectory of decline that often begins in our early 30s. Because the true promise of longer life is a brain that allows us to thrive year by year.”

Study authors Sandi Chapman, PhD, and Mark D’Esposito, MD, speak about recent research breakthroughs during the BrainHealth Week 2026 Science Summit. Screen behind reads: The BrainHealth Project, The BrainHealth Network. 
Credit: Center for BrainHealth



Researchers also identified what they described as a rebound effect. Participants used cognitive strategies to recover, maintain, or even improve brain health during stressful life events, including illness, job loss, and caregiving responsibilities. The findings suggest that brain health is adaptable and can be strengthened using proven techniques.

Personalized Brain Training Shows Lasting Benefits

The research was conducted through The BrainHealth Project, a long-term initiative focused on improving brain health throughout life. Available online and through a mobile app, the program combines brain strategy training, lifestyle guidance, personalized coaching, and ongoing progress tracking through the BrainHealth Index.

“Every brain is as unique as a fingerprint and has potential for growth,” said Lori Cook, PhD, director of clinical research at the Center for BrainHealth. “By moving away from one-size-fits-all solutions, we are empowering people with a personalized blueprint and the agency to continuously invest in their brain health and performance.”

Using a scalable digital platform, Center for BrainHealth has expanded its research beyond the lab into real-world settings across all 50 states and more than 60 countries. Researchers say this approach could help shift public health efforts toward proactive and cost-effective ways to improve brain performance on a global scale.


The birth of modern Man
https://chuckincardinal.blogspot.com/

A Crucial Atlantic Current Is Weakening and Weather Could Change Worldwide

By U. of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, May 15, 2026

A major Atlantic Ocean current system that helps stabilize Earth’s climate has been weakening for almost 20 years, according to new research. 
Credit: NOAA

A giant Atlantic Ocean current that helps regulate Earth’s climate is slowing down, and scientists say the impacts could be global.

A massive Atlantic Ocean circulation system that plays a central role in regulating Earth’s climate has been weakening for nearly 20 years, according to a new study. Scientists say the slowdown spans a large portion of the Atlantic and could eventually alter weather patterns in many parts of the world.

The research, led by scientists at the University of Miami Rosenstiel School of Marine, Atmospheric and Earth Science, provides some of the strongest direct observational evidence so far that the Atlantic Meridional Overturning Circulation (AMOC) is losing strength. Researchers say the findings could improve climate forecasts and help scientists better understand how global warming may affect future weather and ocean conditions.

“A weaker AMOC can shift weather patterns, potentially leading to more extreme storms, changes in rainfall, or colder winters in some regions,” said Shane Elipot, a senior author of the study and physical oceanographer at the Rosenstiel School. “It can also influence sea-level rise along coastlines, affecting communities and infrastructure.”

Deep Ocean Monitoring Reveals Long-Term Trend

To study the current system, researchers examined long-running observations collected from four ocean monitoring arrays positioned along the western side of the North Atlantic, stretching from tropical waters into higher latitudes.

The instruments, anchored to the seafloor, continuously measured pressure, temperature, density, and ocean currents. Scientists used the same analysis method at every site—using changes in bottom pressure to estimate deep ocean flow below about 1,000 meters. By comparing the data across locations and over long periods of time, the team identified a sustained decline in the strength of the overturning circulation.

Measurements from several latitudes revealed a steady weakening in an important section of the AMOC along the Atlantic’s western boundary, extending from the subtropics to mid-latitudes (about 16.5°N to 42.5°N). Because the trend appeared across such a broad region, researchers say it points to a large-scale shift rather than a temporary fluctuation.

Why the AMOC Matters for Global Climate

The AMOC is one of the most important systems controlling climate in the Atlantic region. It helps distribute heat through the ocean, influencing temperatures, weather patterns, and sea levels, especially around the North Atlantic.

Scientists say a slowdown in the circulation could affect European winters, hurricane activity, rainfall patterns, and other climate conditions around the globe.

Researchers also believe measurements taken along the western boundary of the Atlantic may act as an early warning signal for future climate changes. They compared the monitoring approach to a canary in a coal mine because it may provide an efficient way to track long-term changes in this crucial climate-regulating system.

“This research helps scientists better predict how the climate may change in the coming decades—information that governments, businesses, and communities use to prepare for future environmental conditions,” said Elipot.

The study, titled “Meridionally consistent decline in the observed western boundary contribution to the Atlantic Meridional Overturning Circulation,” was published in the April 8 issue of Science Advances.


The Life of Earth
https://chuckincardinal.blogspot.com/

Friday, 15 May 2026

One of the World’s Most Popular Weedkillers May Be Fueling Deadly Superbugs

By M. Dijkstra, Frontiers, May 14, 2026

Glyphosate weedkillers may help drive the spread of antibiotic-resistant bacteria across hospitals and agricultural environments, according to new research. 
Credit: Shutterstock

Scientists have uncovered evidence that one of the world’s most widely used weedkillers may also help dangerous bacteria survive antibiotic treatments.

Each year, antimicrobial resistance (AMR) contributes to an estimated 1.1 million to 1.4 million deaths worldwide. Researchers now say the rise of drug-resistant bacteria may not be driven only by antibiotics. Common weedkillers could also be helping bacteria survive and spread.

“Here we show that the most common species of multidrug-resistant bacteria from hospitals are not only resistant to multiple antibiotic classes but also to high concentrations of the weedkiller glyphosate,” said Dr. Daniela Centrón, a researcher at the Institute of Medical Microbiology and Parasitology in Buenos Aires and the senior author of the study in Frontiers in Microbiology.

“These results suggest that weedkillers—which, unlike antibiotics, are widely applied in agricultural environments—may have the unintended side effect of selecting for AMR among bacterial communities within the soil.”

Scientists Test Environmental and Hospital Bacteria

In 2018 and 2020, Centrón and her team collected 68 bacterial strains from sediment in a protected wetland area in the Paraná Delta north of Buenos Aires. Nearby agricultural land is regularly treated with glyphosate.

Researchers tested how resistant the strains were to 16 commonly used antibiotics, including ampicillin with sulbactam, meropenem, tetracycline, and vancomycin. They also examined resistance to pure glyphosate and glyphosate-based herbicides, which are among the world’s most widely used weedkillers.

The results were compared with 19 bacterial strains taken from local hospitals, including multidrug-resistant species. Another 15 strains came from feedlots and agricultural soils exposed to herbicides.

Hospital Superbugs Show Strong Glyphosate Resistance

The hospital strains showed resistance to between one and 16 antibiotics, confirming widespread antimicrobial resistance. About 74% were resistant to carbapenems, a powerful class of broad-spectrum antibiotics often used as a last-resort treatment. Every hospital strain also showed strong resistance to glyphosate and glyphosate-based herbicides.

“This means that if these bacteria enter the environment through untreated wastewater from hospitals, they could go on to thrive in agricultural areas where glyphosate is used,” said first author Dr Camila Knecht from Dr Centrón’s group.

The Paraná Delta samples included 15 bacterial genera, such as Acinetobacter, Pseudomonas, Exiguobacterium, and Chryseobacterium. All showed at least some resistance to glyphosate and related herbicides, even though those chemicals have never been applied inside the reserve. Enterobacter strains tolerated the highest glyphosate levels, reaching up to 80 milligrams per milliliter (about 2.7 ounces per gallon).

By contrast, Bacillus strains commonly found in soil were highly sensitive. Their growth was inhibited at glyphosate concentrations of just 2.5 milligrams per milliliter (about 0.08 ounces per gallon). Strong glyphosate resistance was also observed in bacteria linked to highly drug-resistant hospital infections.

Glyphosate Resistance Crosses Environmental Boundaries

When researchers created a genetic “family tree” of all 102 bacterial strains, the most glyphosate-resistant strains were often closely related, regardless of where they were found. The same bacterial genera showed resistance in hospitals, agricultural areas, and the Paraná Delta.

“In the environment, the use of glyphosate leads to the evolution of resistant bacteria in impacted soils, whereas the use of antibiotics favors their evolution in hospitals. Bacteria carrying antibiotic resistance genes can spread and breed between those two niches in both directions and in multiple ways, with the water cycle playing a key role in transmission,” concluded coauthor Dr Jochen A. Müller, a group leader at Karlsruhe Institute of Technology.

Glyphosate remains highly controversial. Studies have linked it to harm in arthropods, especially bees, and the International Agency for Research on Cancer classifies it as a probable human carcinogen. France, Belgium, and the Netherlands have banned glyphosate for household use, while Germany prohibits its use in public spaces.

“Policies for the use of any pesticide, as well as its metabolites, should stipulate the requirement for co-selection testing with antibiotics before marketing. Labels should include a warning that genes for antibiotic resistance can spread from glyphosate-contaminated soils to hospitals through untreated water,” counseled Centrón.


The Life of Earth
https://chuckincardinal.blogspot.com/

Vast, Untapped Source of Lithium Found in The US Could Last 300 Years

15 May 2026, By Ivan Farkas

(BJP7images/iStock/Getty Images Plus)

There could be nearly 330 years' worth of lithium hiding beneath the Appalachian Mountains, which stretch like a stony spine across the eastern United States.

New research from the US Geological Survey suggests that the Appalachians may contain around 2.3 million metric tons (2.5 million US tons) of recoverable lithium oxide locked away in pegmatites, the grainy, granite-like rocks that form as water-rich magma cools and crystallizes deep within the Earth.

"This research shows that the Appalachians contain enough lithium to help meet the nation's growing needs – a major contribution to US mineral security, at a time when global lithium demand is rising rapidly," says Ned Mamula, Director of the US Geological Survey (USGS).

Therefore, mapping US mineral resources may help reverse the country's recent reliance on lithium imports.


The Blue Ridge Mountains are part of the Appalachian region. 
(Jonathan Guthrie/Wikimedia Commons/CC BY 3.0)



"The United States was the dominant world producer of lithium three decades ago, and this research highlights the abundant potential to reclaim our mineral independence," Mamula adds.

The soft, silvery lithium is the lightest of the metals and the least dense of the solid elements. It's also one of the oldest elements in existence, as trace amounts were produced during the Big Bang.

Importantly, it is the primary active chemical in lithium-ion batteries, which account for 87 percent of global lithium demand.

These rechargeable batteries power our most essential devices, including smartphones, laptops, electric vehicles, and grid-scale energy storage systems, making lithium indispensable for emerging clean energy initiatives.


Batteries account for 87 percent of global lithium demand.
 (kynny/Canva)

Accordingly, lithium demand is projected to grow over 40 times by 2040, according to the International Energy Agency (IEA).

As a result, the USGS has been tasked with assessing critical mineral deposits throughout the US.

So, as described in the recent study, USGS scientists combined various methods to assess the extent and availability of undiscovered lithium-containing pegmatite deposits in the Appalachian region of the US.

First, the researchers compiled publicly available geological and geochemical data, such as mineral maps, to pinpoint a set of "permissive tracts," or areas that are more or less likely to hold lithium deposits.

They then estimated the quantity of lithium in these potentially undiscovered reserves using the Delphi Method, a structured communication technique involving a panel of more than 20 USGS geoscientists, over a two-day period in July 2024.

The researchers also extrapolated the quality and quantity of the lithium-containing ore by drawing on data from known global lithium deposits, previously determined through methods such as mineral inventory reports.

Finally, the researchers ran 20,000 probabilistic simulations based on the above data to determine the most realistic lithium distribution scenarios, applying an economic filter to gauge how much of this lithium could be feasibly extracted.

The research suggests that 900,000 metric tons of lithium oxide may be economically extractable in the northern Appalachian region, with Maine, New Hampshire, and parts of Vermont deemed the most prospective areas.

Another 1.43 million metric tons could be extractable in the southern Appalachian region, chiefly concentrated in the Carolinas.

Together, the researchers say this huge deposit could meet the lithium needs of the US for 328 years, based on consumption and import rates in 2025.

For perspective, this could furnish every person in the world with 60 smartphones. It's also equivalent to supplying the world with laptops for 1,000 years – though by that point, computers may be more brain than machine, or embedded within our biological tissues.

A USGS graphic showing use cases for the 2.3 metric tons of recoverable lithium oxide discovered throughout the Appalachians (left), as well as the extrapolated concentration of lithium oxide in the northern Appalachian region (right). 
(USGS/Public Domain)

These as-yet untapped reserves are not the only potentially profitable lithium reserves in the US.

An unrelated report recently described a sizable lithium concentration swirling in the salty waters of an ancient limestone aquifer beneath Arkansas, a structure known as the Smackover Formation.

However, actually extracting these reserves may prove more difficult.

Should this lithium eventually make its way from beneath the northern Appalachians to beneath the cover of our smartphones, it will have completed a journey that began more than 300 million years ago with the formation of the supercontinent Pangea.


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