Thursday, 9 April 2026

AI Is Rewriting History – With Outdated Neanderthal Facts

By A. Yates, U. of Maine, April 8, 2026

This is an AI-generated image created with DALL-E 3 that was included in this research study. Its prompt described typical activities, setting, attire, and tools but did not request scientific accuracy. 
Credit: University of Maine

Generative AI can reproduce outdated scientific views, raising concerns about how it represents the past.

Technological progress over the past forty years has transformed computers and mobile devices into a vast, always accessible source of information, placing an immense digital library within easy reach.

Devices such as phones, laptops, tablets, and smartwatches have become deeply embedded in daily routines, making it easier to stay connected, informed, and entertained. Recent advances in generative artificial intelligence are further enhancing these capabilities, enabling people to retrieve information almost instantly. Whether someone is asking about prehistoric environments or checking their heart rate, AI can deliver responses faster than ever before. However, the reliability of those answers remains uncertain.

Generative AI is also shaping how people imagine and interpret the past. This growing influence has drawn attention from researchers across the United States, including Matthew Magnani at the University of Maine.

Magnani, an assistant professor of anthropology, collaborated with Jon Clindaniel, a professor at the University of Chicago who focuses on computational anthropology, to develop a framework grounded in long-established scientific research. They tasked two chatbots with generating images and written descriptions of Neanderthal daily life and reported their results in the journal Advances in Archaeological Practice.

Study design tests bias in outputs

Their analysis showed that the accuracy of AI-generated content depends heavily on the information sources it can access. In this case, both the visual and written outputs relied on outdated scientific material.

Magnani and Clindaniel conducted repeated trials using four different prompts, each run one hundred times. They used DALL-E 3 to create images and the ChatGPT API (GPT-3.5) to produce narratives. Some prompts explicitly asked for scientific accuracy, while others did not. Certain prompts also included additional details, such as clothing or activities, to provide context.

The objective was to examine how misinformation and bias about the past can emerge through everyday interactions with AI systems.

“It’s broadly important to examine the types of biases baked into our everyday use of these technologies,” Magnani said. “It’s consequential to understand how the quick answers we receive relate to state-of-the-art and contemporary scientific knowledge. Are we prone to receive dated answers when we seek information from chatbots, and in which fields?”

The project began in 2023, and within a short period, generative AI has shifted from an emerging technology to a widely used tool. Magnani noted that repeating the study today might yield different results if newer research were better integrated into these systems.

“Our study provides a template for other researchers to examine the distance between scholarship and content generated using artificial intelligence,” Magnani said.

Clindaniel emphasized that AI can be highly effective at processing large volumes of data and identifying patterns, but its usefulness depends on careful application and a strong connection to verified scientific knowledge.
AI reproduces outdated human history

Neanderthal remains were first described in 1864, and scientific interpretations of their behavior and appearance have changed repeatedly since then. Because of these evolving perspectives and remaining uncertainties, Neanderthals provided a useful case for evaluating how well AI systems handle complex and incomplete knowledge.

The generated images reflected outdated ideas from more than a century ago, portraying Neanderthals as primitive, ape-like figures with exaggerated body hair and hunched posture. These depictions also excluded women and children, reinforcing incomplete and biased representations.

The accompanying narratives similarly failed to capture the diversity and complexity of Neanderthal culture described in modern research. Roughly half of the text generated by ChatGPT did not align with current scientific understanding, and for one prompt, that figure exceeded eighty percent.

Both the images and written descriptions also included anachronistic elements such as basketry, thatched roofs, ladders, and materials like glass and metal, which do not match the historical period.

Training data shapes AI knowledge

By comparing the generated outputs with scientific literature from different time periods, Magnani and Clindaniel traced the likely sources of the information used by the AI systems. They found that ChatGPT’s responses aligned most closely with research from the 1960s, while DALL-E 3 reflected material from the late 1980s and early 1990s.

“One important way we can render more accurate AI output is to work on ensuring anthropological datasets and scholarly articles are AI-accessible,” Clindaniel said.

Restrictions introduced by copyright laws in the 1920s limited access to academic research for decades, until open access initiatives began expanding availability in the early 2000s. Future policies governing access to scholarly work are likely to shape how AI systems generate knowledge and influence public understanding of history.

“Teaching our students to approach generative AI cautiously will yield a more technically literate and critical society,” Magnani said.



The birth of modern Man
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Biggest Breakthroughs in Biology: 2025

 Quanta Magazine,  Apr 5, 2026



2025’s most surprising breakthroughs in biology included a finding that a father’s environmental exposures can impact the development of their offspring, research confirming that intelligence evolved independently in birds and mammals, and a new mathematical model reveals that evolution happens in explosive bursts.

TWO PATH'S TO INTELLIGENCE 
A group of international studies comparing brain development in birds and mammals suggests that vertebrate intelligence evolved independently, multiple times. Despite the differences in the brain structures in birds and mammals, the separate evolutionary paths converged on a similar form of functional intelligence. 
Original Papers: "Constrained roads to complex brains" https://www.science.org/doi/10.1126/s... 

 SPERM'S HIDDEN MESSENGERS 
A host of recent research suggests that traits from a father’s lifestyle - such as diet, stress, and nicotine use - can be passed to his children via sperm. Now a new study on exercise offers the strongest evidence yet that the effect of environmental exposures are transmitted by RNAs, which can influence gene expression in the developing embryo. 
Paper - "Paternal exercise confers endurance capacity to offspring through sperm microRNAs" https://www.cell.com/cell-metabolism/... 

 EXPLOSIVE EVOLUTION 
A new mathematical model suggests evolution doesn’t always proceed gradually, but often occurs in rapid bursts, a process known as ‘punctuated equilibrium’. Using this model, researchers found evidence of this evolutionary pattern across a range of diverse systems, including enzymes, cephalopods, and even Indo-European languages.
Paper - "Evolution is coupled with branching across many granularities of life" https://royalsocietypublishing.org/rs...

https://www.youtube.com/watch?v=mf5envOypNU




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Natural Oils vs. Antibiotics: The Swine Study That Could Change Farming

By U. of Arkansas System Div. of Ag., April 8, 2026

In a rare long-term public study that compared the effects of phytochemicals from rosemary and oregano with antibiotic growth promoters, animal scientists with the Arkansas Agricultural Experiment Station, the research arm of the University of Arkansas System Division of Agriculture, found that the natural agents given to weaned pigs supported favorable gut health and growth performance later in their lives by preserving microbial diversity to improve nutrient utilization.
 Credit: UADA photo

Plant-derived phytochemicals support lasting pig growth and gut health, outperforming antibiotics over time.

Efforts to reduce reliance on antibiotic growth promoters in modern pig farming are increasingly turning to plant-derived essential oils as a promising alternative. These natural compounds may offer lasting benefits for animal health and performance.

A rare long-term public study led by researchers at the Arkansas Agricultural Experiment Station examined phytochemicals from rosemary and oregano alongside traditional antibiotic growth promoters. The findings showed that pigs given these plant-based compounds after weaning developed better gut health and maintained stronger growth over time. The benefits appear to stem from preserving microbial diversity, which improves how nutrients are used.

“This study allowed us to look at the lifetime impact from phytochemical exposures,” said Tsungcheng “TC” Tsai, Ph.D., a program associate in the department of animal science for the experiment station, the research arm of the University of Arkansas System Division of Agriculture. “If you just look into the nursery phase—the first 43 days after weaning—and you don’t see any difference, the study is ended, and you don’t really know the true value of those phytochemicals.”

Tsai served as the corresponding author of the study, which was published in Animal Research and One Health.


Tsungcheng “TC” Tsai, Ph.D., a program associate in the Department of Animal Science for the Arkansas Agricultural Experiment Station, tends to a pig at the station’s Savoy Research Complex in Fayetteville, Arkansas.
Credit: UADA photo



Concerns Over Antibiotic Use and Environmental Impact

The study included microbiome analysis conducted in partnership with the University of Arkansas for Medical Sciences.

While antibiotics remain important in veterinary care, Tsai explained that their widespread use has contributed to growing antimicrobial resistance, prompting restrictions or bans in several countries.

High levels of dietary zinc are also commonly used to prevent postweaning diarrhea. However, excessive zinc excretion can harm the environment by accumulating as a heavy metal. Since pig waste is often used as fertilizer, this buildup can reach levels that damage plant health.

Previous research has shown that essential oils from plants such as rosemary and oregano can improve animal health across species, including poultry, fish, and pigs. However, most studies have focused only on short-term effects during the early nursery stage.

Challenges in Early Pig Development and Study Design

The period immediately after weaning is one of the most stressful stages in a pig’s life, both physically and immunologically, Tsai said. Sudden changes in diet and environment, along with separation from the mother, disrupt gut development and destabilize the microbial balance. These early conditions can influence feed efficiency, growth patterns, and overall production outcomes later on.

To explore long-term effects, researchers assigned 192 piglets into four groups after weaning. One group received no treatments, while another was given the antibiotic carbadox along with high dietary zinc. The remaining two groups received feed supplemented with phytochemicals derived from oregano and rosemary.


Tsungcheng “TC” Tsai, Ph.D., is a program associate in the Department of Animal Science for the Arkansas Agricultural Experiment Station, the research arm of the University of Arkansas System Division of Agriculture. 
Credit: UADA photo



One phytochemical group received oregano extract at 300 grams per ton of feed (about 0.66 pounds per 2,000 pounds of feed), while the other received a blend of oregano and rosemary extracts with sodium humates at 900 grams per ton (about 2 pounds per 2,000 pounds of feed). Sodium humate, derived from sedimentary rock, has anti-diarrheal, antiviral, and anti-inflammatory properties.

To reflect standard industry practices, antibiotics and zinc were used only during the early postweaning stage. In contrast, phytochemicals were fed continuously, allowing researchers to evaluate their long-term effects.

Growth Performance and Long-Term Outcomes

Researchers tracked growth across seven phases, including nursery, growing, and finishing stages.

Pigs that received antibiotics initially grew faster and reached higher body weights, but this advantage faded once the treatments stopped.

By day 155, pigs fed the combination of oregano, rosemary, and sodium humate achieved the highest final body weight and the most efficient feed conversion among all groups.

“From a production perspective, these patterns may offer complementary or alternative strategies for growth promotion, but their implications should be interpreted cautiously,” the researchers noted in their conclusion.

Behavioral and Microbiome Findings

Although not formally measured in the study, Tsai noted that pigs receiving phytochemicals appeared less aggressive toward one another.

Microbial analysis supported the performance results. Phytochemicals improved long-term productivity and helped restore a healthier gut microbiome. Unlike antibiotics and high zinc exposure early in life, they did not cause harmful shifts in microbial composition.

Researchers collected rectal swabs from one pig in each group at multiple time points, including days zero, 16, 126, and 155, to compare microbial changes.

Pigs treated with antibiotics and zinc showed reduced microbial diversity and a higher presence of potential pathogens. In contrast, pigs fed oregano alone had greater levels of beneficial bacteria linked to gut health and serotonin-related development.

Microbial Diversity and Health Implications

“These compounds may not give the instant response producers often see with antibiotics, but over time they appear to help condition the gastrointestinal tract and microbiome, so pigs handle stress better later in life,” Tsai said.

The long-term study was a long time in the making for Tsai, who, as a boy, was intrigued by the different growth rates of the pigs on his grandparents’ small farm. His curiosity continued at the University of Georgia, where he earned his graduate degrees in animal nutrition. He then gained more knowledge of immunology and microbiology as a program associate with the University of Arkansas System Division of Agriculture.

“We come to a point where we know some of the basic mechanisms that can result in the advantage of the phenotype response by certain types of treatments, but the challenge we still have nowadays is that we cannot identify a single solution to all types of production systems that is able to be as effective, in the broad spectrum, when compared to antibiotics. We have to think about customizing, or conditioning production systems to what kind of treatment would probably be better.”

At the Savoy Research Complex in Fayetteville, Tsai observed that each generation of pigs differs slightly in health and performance, highlighting the need for adaptable approaches.

Future Research and Industry Implications

“It’s still a thing that we need to further look into, and see, to learn more,” Tsai said of the phytochemicals. “I think the good thing is that we are in a time that allows us high-end molecular science with techniques we can adapt into the production side, and the nutrition side. We have the people with expertise that we can collaborate with and get the bigger picture or better understanding of what’s going on.”

The findings suggest that farmers have viable natural options to support animal health while reducing dependence on antibiotics, according to Michael Looper.

“It’s an encouraging step toward more sustainable and responsible pork production,” Looper said. “Consumers want food that’s raised responsibly, and this study gives swine farmers more natural tools to do just that. It’s exciting to see options that support animal health while helping produce pork that people can feel good about.”



The Life of Earth
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Wednesday, 8 April 2026

Exercise Can Protect Your Joints – Here's What You Should Try

06 April 2026, By G. Waddington, The Conversation

(mixetto/E+/Getty Images)

Growing older has plenty of upsides – but achy joints are not one of them.

As we age, the joints that once handled every bend and fall start to weaken. This is because the amount of cartilage, a tough but flexible kind of connective tissue, and fluid in your joints decreases over time.

This may lead some people to avoid activities such as exercise. But with the right approach, exercise can actually help protect your joints.

Let's dive into the science.

Why joints matter

Each joint is cushioned by articular cartilage, a type of specialised tissue that covers the ends of bones. This cartilage protects the joints and creates a smooth surface for motion.

A thick liquid known as synovial fluid also helps lubricate your knees, hips and shoulders. It does this by reducing friction between your cartilage and joints. Synovial fluid also supplies cartilage with key nutrients.


Joints can become stiff and painful with age, which may be symptoms of osteoarthritis. 
(angkhan/Canva)



However, cartilage isn't very good at repairing itself. This is partly because it doesn't have its own blood supply.

The gradual breakdown of cartilage is known as osteoarthritis, a condition which affects more than 500 million people worldwide. People with osteoarthritis often feel the most pain in weight-bearing joints such as the knees, hips and spine.

How exercise impacts your joints

The body distributes synovial fluid through motion. So exercise helps gets this fluid, and the nutrients it contains, to cartilage.

Meanwhile, muscles around your joints act as shock absorbers. So strengthening your muscles, including through exercises such as weightlifting, helps to reduce the pressure placed on your joints.

Research suggests strength exercises targeting the quadriceps, a group of muscles at the front of the thigh, are particularly effective at reducing joint pain.

A landmark Cochrane review assessed all the relevant evidence looking at the effect of exercise on osteoarthritis. It found exercise reduces pain and improves function in people with knee osteoarthritis. It also showed exercise has a similar impact as anti-inflammatory drugs, but without the same side effects.

Exercise may also help maintain proprioception, the body's ability to sense its own position and movement. However, proprioception declines with age. So as you get older, your brain is less able to register these signals and may cause your joints to bear weight unevenly. This wears down your joints quicker.

However, exercising on varied and even unstable surfaces can reduce this wear-and-tear process. It forces your ankle, knee and hip joints to quickly adjust their movements, keeping them engaged and flexible.

What about low-impact exercise?

Low-impact exercise refers to exercises where you keep at least one foot on the ground, or support the body in some other way. This kind of exercise reduces the amount of weight and force placed on joints.

Examples of low-impact exercise include swimming and water aerobics. Both involve being suspended in water, which can support up to 90% of your body weight. Cycling may also be beneficial for your joints, particularly your knees.


Tai chi, a gentle form of exercise based on gentle movements and breathing techniques, is another option. Research suggests it may be as effective as physical therapy for people with knee osteoarthritis. Yoga can also help strengthen the muscles around your joints and improve your overall flexibility.

Walking deserves a special mention. Walking on uneven terrain, such as on grass, gravel or bush trails, can help maintain proprioception. One 2026 study found unstable surface training significantly improves postural control, or the ability to remain stable, in older adults.

Another systematic review found exercises which challenged participants' balance reduced fall rates by roughly 23%. This is important, given falls are the leading cause of injury-related death in adults over 65.

I've never done low-impact exercise. How can I start?

Here are three tips to make low-impact exercise as safe and effective as possible.

1. Start small

You don't need any fancy equipment to start. Where possible, opt to walk on uneven surfaces, such as grass, sand or gravel, instead of pavement. Even ten minutes walking across a park lawn will improve your joint movement.

You can also practise standing on one leg, for example while brushing your teeth. It's best to start on firm ground first, aiming to stand on each leg for 30 seconds. You can then progress to standing on a folded towel or foam pad. Importantly, you should master each task or level of difficulty before advancing.

2. Use support

Safety is paramount. Always perform low-impact exercises near something you can hold for support, such as a park bench or bathroom vanity. If you're walking for exercise, walking poles are an excellent option. Importantly, never exercise on unstable surfaces when you're tired.

3. Get advice

No exercise is risk-free. For example, holding a yoga pose beyond your range of motion may injure your lower back, shoulders or knees. Doing deep squats or lunges with poor form can put unnecessary strain on your knee joint.

So before you start, speak to a certified exercise physiologist or physiotherapist. They can help you design a tailored exercise program.

The bottom line

Our joints are subject to the inevitable wear-and-tear of age, but low-impact exercise can help. So it's worth trying, no matter how young or old you are.



The Life of Earth
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Climate Change Is Altering a Key Greenhouse Gas in a Way Scientists Didn’t Expect

By B. Bell, U. of California Irvine, April 7, 2026

Scientists have uncovered evidence that the atmospheric behavior of nitrous oxide is changing in unexpected ways, with implications for both climate and ozone. 
Credit: Shutterstock

The lifetime of nitrous oxide is decreasing more quickly than expected, which is changing climate projections.

Scientists at the University of California, Irvine report that climate change is accelerating the breakdown of nitrous oxide in the atmosphere. This gas is both a powerful greenhouse contributor and a key ozone-depleting substance, and its faster removal is adding new uncertainty to climate projections for the remainder of the 21st century.

Drawing on two decades of satellite measurements from NASA’s Microwave Limb Sounder (2004-2024), researchers from UC Irvine’s Department of Earth System Science determined that the atmospheric lifetime of N2O is shrinking by about 1.4 percent per decade.

This trend reflects climate-driven changes in stratospheric temperature and circulation patterns, and its magnitude is similar to the spread between the emissions scenarios used by the Intergovernmental Panel on Climate Change.

Michael Prather, UC Irvine professor of Earth system science and co-author of a new paper in PNAS on the longevity of nitrous oxide in Earth’s atmosphere.
 Credit: UC Irvine



The findings were published in Proceedings of the National Academy of Sciences.

“The change in the life cycle of atmospheric nitrous oxide is a critical piece of the puzzle that has been largely overlooked,” said co-author Michael Prather, UC Irvine professor of Earth system science. “While most research has focused on projecting changing N2O emissions from human activities, we’ve shown that climate change itself is altering how quickly this gas is destroyed in the stratosphere – and this effect cannot be ignored in future climate assessments.”

A major greenhouse gas at stake

Nitrous oxide ranks as the third most important long-lived greenhouse gas after carbon dioxide and methane, and it is now the leading ozone-depleting substance linked to human activity. Concentrations reached roughly 337 parts per billion in 2024 and are rising at close to 3 percent per decade. Prather emphasized that accurately tracking its behavior is essential for both climate mitigation strategies and efforts to protect the ozone layer.

The study shows that estimating future N2O levels requires more than accounting for emissions from agriculture, industry, and natural sources. It also depends on how climate change alters the stratosphere, where this gas is broken down. This atmospheric region extends from about 10 to 50 kilometers above Earth’s surface.

Observations reveal accelerating decay

According to the findings, the average atmospheric lifetime of nitrous oxide is currently about 117 years, but it is shortening by roughly one and a half years each decade.

This trend aligns with observed changes in stratospheric circulation and temperature. When extended to 2100, the shortening lifetime could alter atmospheric N2O concentrations to a degree comparable with major shifts in greenhouse gas emissions scenarios used by the Intergovernmental Panel on Climate Change.

The researchers explain that while rising carbon dioxide warms the lower atmosphere, it cools the stratosphere. This cooling changes the chemistry that destroys N2O and produces nitrogen oxides, which contribute to ozone depletion.

“This cooling, combined with changes in atmospheric circulation patterns, is speeding up the transport of N2O to the regions where it’s destroyed. It’s a feedback loop that adds another layer of complexity to climate projections,” explained co-author Calum Wilson, a UC Irvine graduate student researcher in Earth system science.

Lifetime shifts rival emissions scenarios

The team found that the uncertainty caused by changes in N2O lifetime is similar in scale to the differences among Shared Socioeconomic Pathways, which are used to model future greenhouse gas concentrations under varying policy and development conditions.

For instance, continuing the observed trend in lifetime reduction would lower projected N2O levels by an amount comparable to moving from a high-emissions pathway (SSP3-7.0) to more moderate pathways such as SSP1-2.6 or SSP2-4.5, even if emissions themselves remain unchanged.

Prather noted that these results could affect multiple areas, including climate projections through 2100, calculations of N2O’s global warming potential, assessments of ozone depletion, international climate agreements such as the Paris Agreement, and strategies for reducing emissions from agriculture and industry.

How nitrous oxide is removed

Nitrous oxide builds up in the lower atmosphere from natural sources like soils and oceans, as well as human activities such as farming, fossil fuel use, and industrial production. It is then carried upward into the tropical stratosphere by large-scale atmospheric circulation, where it is broken down by ultraviolet radiation and chemical reactions.

About 90 percent of N2O destruction occurs through sunlight-driven breakdown in the middle and upper stratosphere, at altitudes between 25 and 40 kilometers. The remaining 10 percent is removed through reactions with excited oxygen atoms.

During this breakdown process, some N2O molecules generate nitrogen oxides that help destroy ozone. This makes nitrous oxide the most significant human-produced ozone-depleting substance today, following the global phaseout of chlorofluorocarbons under the Montreal Protocol, which was based on Nobel Prize-winning work by UC Irvine Professor F. Sherwood Rowland and postdoctoral researcher Mario Molina.

Models miss key atmospheric feedbacks

The authors emphasize that although observations and theory strongly indicate that climate change is altering N2O lifetime, more advanced chemistry-climate modeling is needed to fully capture the feedbacks involved. This includes understanding the full sequence from N2O to nitrogen oxides to ozone to N2O photolysis (breakdown by sunlight) and back to its atmospheric lifetime. Additional research is also needed on regional differences in stratospheric circulation, interactions with other atmospheric changes, and improved projections under different climate pathways.

“This work highlights a gap in current Earth system models,” Prather added. “Stratospheric chemistry and dynamics present uncertainties in projecting N2O that are as large as uncertainties across different emissions scenarios. We need to incorporate these effects into the models used for international climate assessments.”


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Scientists Think Our Eyes Began as a Single Eye on Top of The Head

08 April 2026, ByG. Kafetzis & D. Nilsson, The Conversation

(Sakis Lazarides/Canva)

It's easy to take our eyes for granted. But our recent research shows they took an incredible evolutionary journey to reach their current familiar form.

It has long been known that our (vertebrate) eyes differ fundamentally from the ones of our distant relatives (invertebrates), because of their cell composition and how they develop before birth. However, answers to why or how these differences first emerged long remained elusive.

Our study suggests that our eyes descended from a worm-like ancestor that was roaming the oceans 600 million years ago. The same also applies to all bilateral animals, meaning animals whose bodies can be divided into roughly mirror-image left and right halves.

As part of our study, we surveyed 36 major groups of living animals (covering nearly all bilateral animals) to see where their eyes and light-sensing cells are located and what they do.

A pattern emerged. We discovered that eyes and light-sensing cells are consistently found at two separate locations: paired on both sides of the face, and at the midline of the head, on top of the brain.

Across the animals we looked at, cells in the paired position are used to steer movements, while their midline counterparts tell day from night and up from down.

We concluded that an ancient worm-like ancestor of all vertebrate animals lost the "steering" pair of eyes when it adopted a mostly stationary lifestyle 600 million years ago, burrowing into the seabed. In becoming a filter feeder with no need to move around, the energetically expensive type of paired eyes was rendered useless and costly.

However, this lifestyle change left the light-sensing cells in the middle of its head unscathed, because the animal still needed to sense the time of day and distinguish between up and down. Although the paired eyes were gone, the light-sensing cells in the midline developed into a small midline eye.

Possibly within a few million years, this animal changed lifestyle again. A return to swimming reintroduced the need to control steering and measure its own body motion for efficient filter-feeding (sifting food out of water) and avoiding predators.

Repeated lifestyle changes drove the unique evolution of vertebrate eyes. 
(Kafetzis et al., Curr. Biol., 2026)

This pushed evolution to develop the midline eye by forming small eye cups on each side. These eye cups later separated from the midline eye, moved out to the sides of the head, and formed new paired eyes: our eyes.

The loss and regain of vision happened between 600 and 540 million years ago. Components of the midline eye remained and became the pineal organ in the brain, which produces and releases the sleep hormone melatonin.

In many vertebrates, the pineal organ receives light through a transparent (unpigmented) region in the middle of the head.

However, in the mammalian lineage, the pineal organ lost its light-sensing capacity – possibly because early mammals were active at night and hid during daytime. So the eyes, which were more sensitive, took over the light detection, which drives melatonin release and sleep.

Eyes of all shapes and sizes

Those animals that did not lose the worm-like ancestor's original paired light-sensing cells comprise most invertebrates around today, since they descended from a branch of the evolutionary tree that never adopted a static lifestyle.

Such animals include crustaceans, insects, spiders, octopuses, snails, and many groups of worms. These animals still have modern versions of the original sets of light-sensing cells.

The paired eyes of insects and crustaceans are compound eyes, with an array of tiny and densely packed lenses per eye. Instead of compound eyes, octopuses and snails have camera-type eyes with a single lens.

In fact, octopus and snails independently evolved the same eye design and visual performance as us vertebrates.

However, our retina – the light-sensitive layer at the back of our eyes – has over 100 types of neurons (mice have even more – 140), compared to a mere handful in octopus and snails. This makes it almost as complex as our cerebral cortex – the outer and largest part of our brain.

Scientists have thought that in the evolution of our eyes, this complexity emerged fairly late. Similarities between light-sensing cells in the brain and paired eyes informed earlier hypotheses about a simple, pineal organ-like eye early in its evolution. In our work, however, we argue that a lot of this complexity predates the retina.

As such, it is likely to have been present already in the "cyclops" ancestor eye. This has broad implications for the origin and wiring of neural circuits in our retina and brain alike.

For us vertebrates, the evolution of our eyes and brain is intimately linked. The emergence of new paired eyes is a fundamental part of this picture, since the eyes allowed for the complex behavior that calls for cognition and large brains.

Without the eyes, we would not just be humans without eyes; we would not exist at all, nor would any of the other vertebrates.



The Life of Earth
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Tuesday, 7 April 2026

Scientists Engineer “Tumor-Eating” Bacteria That Devour Cancer From Within

By U. of Waterloo, April 7, 2026

A new strategy uses genetically programmed bacteria to detect when enough of them have gathered inside a tumor – then switch on survival mechanisms at just the right moment. 
Credit: Shutterstock

Researchers are exploring an unconventional cancer treatment that uses engineered bacteria to target the unique, oxygen-free environments inside tumors.

A research team led by the University of Waterloo is developing a new way to treat cancer by engineering bacteria that can consume tumors from the inside.

“Bacteria spores enter the tumor, finding an environment where there are lots of nutrients and no oxygen, which this organism prefers, and so it starts eating those nutrients and growing in size,” said Dr. Marc Aucoin, a chemical engineering professor at Waterloo. “So, we are now colonizing that central space, and the bacterium is essentially ridding the body of the tumor.”

The approach relies on Clostridium sporogenes, a bacterium commonly found in soil that can grow only in completely oxygen-free conditions.

The center of a solid cancerous tumor is made up of dead cells and lacks oxygen, creating an ideal environment for this bacterium to thrive and multiply.


Waterloo researchers (L to R) Dr. Brian Ingalls, Dr. Sara Sadr, and Dr. Marc Aucoin have engineered bacteria to treat cancer by eating tumors from the inside out.
 Credit: University of Waterloo



However, there is a key limitation. As the bacteria spread toward the outer layers of tumors, they encounter small amounts of oxygen. This exposure causes them to die before they can fully eliminate the tumor.

To overcome this challenge, researchers introduced a gene from a related bacterium that is better able to tolerate oxygen. This change allows the engineered bacteria to survive longer near the tumor’s outer regions.

Engineering Bacteria to Survive

The team also developed a way to activate the oxygen-tolerance gene only when needed, which helps prevent the bacteria from growing in oxygen-rich areas such as the bloodstream. They achieved this using a natural process called quorum sensing.

Quorum sensing involves chemical signals released by bacteria. When enough bacteria accumulate inside a tumor, the signal becomes strong enough to switch on the oxygen-tolerance gene, ensuring it is not activated too early.

In one study, researchers showed that Clostridium sporogenes can be modified to tolerate oxygen. In a follow-up study, they tested the quorum-sensing system by engineering the bacteria to produce a green fluorescent protein.

“Using synthetic biology, we built something like an electrical circuit, but instead of wires we used pieces of DNA,” said Dr. Brian Ingalls, a professor of applied mathematics at Waterloo. “Each piece has its job. When assembled correctly, they form a system that works in a predictable way.”

Next Steps Toward Clinical Testing

Researchers now plan to combine the oxygen-tolerance gene with the quorum-sensing control system in a single bacterium and test it on tumors in preclinical trials.

The promising project grew out of work by PhD student Bahram Zargar, who was supervised by Ingalls and Dr. Pu Chen, a retired professor of chemical engineering at Waterloo.


The Life of Earth
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Childhood Junk Food May Rewire the Brain for Life

By U. College Cork, April 6, 2026

Early exposure to high-fat, high-sugar diets may rewire how the brain regulates eating in ways that persist into adulthood, even after diet and weight improve. New findings suggest these hidden changes are linked to key brain regions involved in appetite and energy balance. 
Credit: Shutterstock

Early diet may leave hidden, long-term imprints on the brain’s control of eating.

Eating unhealthy foods early in life can lead to lasting changes in the brain and eating behavior, but gut bacteria may help restore healthier patterns, according to a new study from University College Cork (UCC).

Researchers at APC Microbiome, a leading institute at UCC, found that a high-fat, high-sugar diet during early development can alter how the brain controls eating over the long term. These effects can persist even after the diet improves and body weight returns to normal.

Children today are surrounded by environments where high-fat, high-sugar foods are easy to access and heavily promoted. These foods are commonly present at birthday parties, school events, sports activities, and even used as rewards for good behavior, making them a regular part of early life.

The study highlights how this repeated exposure can have lasting consequences. Regular consumption of energy-dense, nutrient-poor foods during childhood may shape food preferences and reinforce unhealthy eating habits that continue into adulthood.

Lasting Effects of Early Diet on the Brain

Published in Nature Communications, the research also points to possible ways to reduce these long-term effects. Interventions targeting the gut microbiota, including a beneficial bacterial strain (Bifidobacterium longum APC1472) and prebiotic fibers (fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), naturally present in foods such as onions, garlic, leeks, asparagus, and bananas, and widely available in fortified foods and prebiotic supplements), showed potential when used across the lifespan.

In a preclinical mouse model, early exposure to a high-fat, high-sugar diet led to lasting changes in feeding behavior that continued into adulthood. These changes were linked to disruptions in the hypothalamus, a key brain region that regulates appetite and energy balance.

What we eat early in life matters

“Our findings show that what we eat early in life really matters,” said Dr. Cristina Cuesta-Martí, first author of the study. “Early dietary exposure may leave hidden, long-term effects on feeding behavior that are not immediately visible through weight alone.”

The findings indicate that poor diets early in life can disrupt brain pathways involved in controlling eating, with effects that persist into adulthood. This pattern may increase the risk of obesity later on, even if body weight appears normal at earlier stages.

Targeting the gut microbiota helped reduce these long-term effects. The probiotic strain Bifidobacterium longum APC1472 significantly improved feeding behavior while causing only minor changes to the overall microbiome, suggesting a focused mechanism. In contrast, the prebiotic combination (FOS+GOS) produced broader changes in gut microbiota composition.

Targeting the gut microbiota can mitigate the long-term effects

Dr. Harriet Schellekens, lead investigator of the study, added, “Crucially, our findings show that targeting the gut microbiota can mitigate the long-term effects of an unhealthy early-life diet on later feeding behavior. Supporting the gut microbiota from birth helps maintain healthier food-related behaviors into later life.”

Professor John F. Cryan, Vice President for Research & Innovation at UCC and collaborator on the study, said: “Studies like this exemplify how fundamental research can lead to potential innovative solutions for major societal challenges. By revealing how early-life diet shapes brain pathways involved in the regulation of feeding, this work opens new opportunities for microbiota-based interventions.”



The Life of Earth
https://chuckincardinal.blogspot.com/

Neanderthals Used Ancient Gloop as Antibacterial Medicine, Study Suggests

05 April 2026, By I. Farkas

Birch bark pitch. 
(Jorre/Wikimedia Commons/CC BY-SA 3.0)

Relatives of modern humans may have created and used a sticky substance both as a glue and to treat their wounds, preempting modern medicine by as much as 200,000 years, a new study suggests.

Researchers have known that Neanderthals used birch tar, a viscous substance derived from birch bark, to glue spear points onto handles in a process known as hafting.

This substance has been found across Europe, and it served multiple purposes, including as some of history's oldest water sealant and Hubba Bubba.

"Alongside these findings, there is also growing evidence of medicinal practices and the use of plants among Neanderthals, which is why we were interested in the use of birch tar in this context," explains Tjaark Siemssen, an archaeologist at the University of Cologne and Oxford University and the study's lead author.

So in the recent study, researchers at the University of Cologne, the University of Oxford, and the University of Liège recreated this birch tar using the ingredients and processes that were possibly utilized by Neanderthals.

Then, researchers at Cape Breton University in Nova Scotia, Canada, performed biological tests to confirm the tar's medicinal properties.

"That is exactly what we proved. The substance Neanderthals made 200,000 years ago, we now know, also possesses antibacterial properties," says Matthias Bierenstiel, a professor of chemistry at Cape Breton University and study co-author.



'Chewed' pieces of birch tar analyzed. 
(White et al., Proc. R. Soc. B, 2025)



To recreate this deeply historical glue-medicine, the researchers collected bark from two types of (dead) birch trees widely documented during the Late Pleistocene, circa 129,000 to 11,700 years ago.

They then used three tar extraction methods to turn the bark into a gooey, spreadable compound.

The first method involves heating birch bark in a tin. This technique is inspired by the Mi'kmaq nation, the Indigenous people of Nova Scotia, who for generations have used birch tar as a cornerstone of their traditional pharmacy.

The other two techniques recreated what Neanderthals may have done. In one method, the researchers burned birch bark in a sealed underground pit, achieving a dry distillation that occurs in the absence of oxygen.

In the second period-specific method, the researchers burned birch bark next to a hard surface, a stone, and then scraped off the tar that condensed on the stone's surface.

The tar samples obtained through these different methods showed varying but positive antibacterial activity against Staphylococcus aureus, a bacterium associated with wound infections.

Yet perhaps unsurprisingly, the tar was not as effective as the common antibiotic Gentamicin. Additionally, the tar had no effect against the infamous Escherichia coli bacterium, which is commonly found in the lower intestine.

The findings suggest that ancient populations used birch tar to specifically treat wounds or skin conditions at risk of infection.

So how did our ancient relatives discover these secrets? Easily, since scientists say birch tar gets everywhere whenever anyone is trying to do anything with it. Plus, a little tar goes a long way: just 0.2 g can cover 100 cm2 of skin.

Importantly, this ancient knowledge may help fight antibiotic-resistant and hospital-acquired infections, as it's effective against S. aureus. Alarmingly, this pathogen is capable of becoming resistant to every class of currently used antibiotic and causes around 500,000 hospitalizations in the United States every year.

"Our findings show that it might be worthwhile to examine targeted antibiotics from ethnographic contexts – or, as in this case, from prehistoric contexts – in greater depth," concludes Siemssen.

Like other aspects of history, healthcare may be cyclical, so when new interventions become ineffective, it can be worthwhile to draw inspiration from (incredibly) older options.



The Life of Earth
https://chuckincardinal.blogspot.com/

Monday, 6 April 2026

Chuck's picture corner to April 5th, 2026

It's been a week of yard work, feels good to get out of the house each day for some exercise. My body has enjoyed less stiffness and more vigour as the week went on.

This morning Apl. 6 more snow and faster flooding in the basement. I had to pump for a half hr. this morning.

sunset through the back room window, last evening about 7:20

cloud gazing,

sunset off the back porch a few days ago

The silver maple out front is really starting to bud out

just an old stick, lol

raking the old front walk sedum bed

the same bed as the last pic a week later.

out front at the number sign

and across the driveway

after this clean up I went back and cut the hydrangea back to the ground

coming to the door

lots of water in the barnyard the ducks love it.

The start to another day

first cleanup of the season



Enjoy
https://chuckincardinal.blogspot.com/


Scientists Engineered a Plant to Produce 5 Different Psychedelics at Once

02 April 2026, By M. Starr

(Victor de Schwanberg/Science Photo Library/iStock/Getty Images)

What do plants, toads, and mushrooms have in common? They can all produce psychedelic substances – and now their powers have been combined in one plant, like a trippier Captain Planet.

In a wild first, scientists have taken the genes these organisms use to make five natural psychedelics and introduced them into a tobacco plant (Nicotiana benthamiana), which then produced all five compounds simultaneously.

As interest grows in psychedelics as potential treatments for illnesses such as depression, anxiety, and PTSD, the newly developed system could offer scientists a new way to produce these compounds for research purposes.

"[Our] strategy established a heterologous plant system for the production of five prominent therapeutically valuable compounds, their derivatives, and nonnatural plant analogs, providing a starting point for their production in plants," writes a team led by researchers at the Weizmann Institute of Science in Israel.

Where DMT accumulates in the tissues of various plants. 
(Berman et al., Sci. Adv., 2026)

Tryptamine psychedelics are a class of compounds that includes psilocin, psilocybin, and a number of dimethyltryptamine (DMT) compounds. The ability to produce these substances has emerged in diverse organisms across the tree of life – plants, fungi, and animals.

In recent years, a number of studies have shown that tryptamine psychedelics may represent an untapped resource when it comes to mental health treatments.

However, progress in this field remains limited, in part due to regulatory restrictions, underscoring the need for more research. This creates practical challenges for scientists.

"Traditionally, the supply of psychedelics relies on natural producers, mainly plants, fungi, and the Sonoran Desert toad," the researchers write.

"Harvesting these organisms for their psychoactive compounds raises ecological and ethical concerns, being increasingly threatened by habitat loss and overexploitation."

In an effort to tackle this, plant scientists Paula Berman and Janka Höfer and their team set out to map and rebuild the biochemical pathways behind these compounds.

They identified the key genes used by two plants – Psychotria viridis and Acacia acuminata – to make DMT, and the step-by-step chemical pathways involved in producing the compound.

Then, they combined these with genes and pathways already known from psychedelic mushrooms (Psilocybe cubensis) and the cane toad (Rhinella marina), added supporting enzymes from rice and cress, then genetically introduced the combined genetic toolkit and kaboodle into tobacco plants (Nicotiana benthamiana).

The tobacco was chosen not because of its own drug production, but because it's basically the lab rat of plant species, with its fast growth.

Finally, the team carefully monitored the plant's production of five psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin from mushrooms; and bufotenin and 5-MeO-DMT from toads.

The modified tobacco plants were found to produce all five compounds simultaneously. Because the different production pathways compete for the same resources, some compounds were produced in lower quantities than in their original sources.

However, the production was high enough to suggest that with a bit more tweaking, the system could function as a biological tryptamine factory for researchers.

Berman, Höfer, and their team also took it a step further. By tweaking the enzymes involved in the tryptamine production pathway, the researchers were able to produce modified versions of the compounds that do not naturally occur in plants, and which may also have therapeutic value.

With further research, the system could be optimized to research requirements, or even help design new compounds tailored for specific therapeutic applications.

"Blending catalytic functions across the tree of life, coupled with metabolic engineering guided by rational protein design of mutant enzymes, enabled substantially more efficient in planta production of the indolethylamine components," the researchers write.

"This work establishes a versatile platform for concurrent biosynthesis and diversification of psychoactive indolethylamines, paving the way for their production in plants."


The Life of Earth
https://chuckincardinal.blogspot.com/