https://medicalxpress.com/news/2021-06-life-mice-average.html
In a paper recently published by Nature Communications, an international team of researchers, led by Bar-Ilan University in Israel, report that transgenic mice express high levels of the SIRT6 gene and show that their life expectancy can be increased by an average of 30% in both males and females. The mice exhibited significant improvement in overcoming a variety of age-related diseases and conducted the same level of vigorous activity as young mice, without becoming frail. Through a variety of methods and analyses, the mechanism through which SIRT6 facilitates healthy aging was deciphered.Photo: Lead author Prof. Haim Cohen, of Bar-Ilan University, holds a well microplate used to monitor the activity of SIRT6 gene expression.
Credit: Bar-Ilan University
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means. Animals usually are made transgenic by having a small sequence of foreign DNA injected into a fertilized egg or developing embryo. (added by CC)
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means. Animals usually are made transgenic by having a small sequence of foreign DNA injected into a fertilized egg or developing embryo. (added by CC)
Cumulative evidence suggests that diet and metabolism are key targetable regulators of healthy lifespan. Prof. Haim Cohen, Director of the Sagol Healthy Human Longevity Center at Bar-Ilan University, focuses much of his research on the SIRT6 protein that is involved in regulating many biological processes, such as aging, obesity, and insulin resistance.
In a study just published in the journal Nature Communications, an international team led by Cohen and his Ph.D. student Asael Roichman—together with Prof. Rafael de Cabo, of the National Institute on Aging at the National Institutes of Health, Prof. Manuel Serrani, of the Institute for Research in Biomedicine in Barcelona, and Prof. Eyal Gottlieb from the Technion—report that transgenic mice express high levels of the SIRT6 gene, and show that their life expectancy can be increased by an average of 30% in both males and females. Translated into human terms this means that a 90-year-old could live until nearly 120!
Furthermore, the mice exhibited significant improvement in overcoming a variety of age-related diseases, such as cancer and blood disorders. Beyond this, strikingly, they were able to conduct the same level of vigorous activity as young mice, and didn't become frail.
Next, through a variety of biochemical methods and metabolic analyses the researchers deciphered the mechanism through which SIRT6 acts as a type of "fountain of youth", facilitating healthy aging. They showed that older animals lose the ability to generate energy in the absence of external energy sources, such as a short fast. On the other hand, the engineered mice maintained an enhanced energy generation capacity from other storage, such as the breakdown of fats and lactic acid. By doing so, they created sugar utilized for energy in muscle and specifically in the brain. In fact SIRT6 activates a physical response that is identical to diets that increase longevity.
"This discovery, combined with our previous findings, shows that SIRT6 controls the rate of healthy aging," says Prof. Cohen, of Bar-Ilan University's Mina and Everard Goodman Faculty of Life Sciences. "If we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications." Today, Cohen's lab is developing methods for extending healthy life based on these findings.
Recommend this post and follow
The birth of modern Man
No comments:
Post a Comment