Tuesday, 31 December 2024

First self-charging supercapacitors developed: Storage device capable of storing solar energy efficiently

Dec. 30, 2024, by Daegu Gyeongbuk Inst. of Sci. and Tech.

Graphical abstract. Schematic diagram and atomic structure of Ni2(CO3)(OH)2 unary compound and Ni2–xMx (CO3)(OH)2 binary compound. 
Credit: Energy (2024). DOI: 10.1016/j.energy.2024.133593

A joint research effort has developed a high-performance self-charging energy storage device capable of efficiently storing solar energy. The research team has dramatically improved the performance of existing supercapacitor devices by utilizing transition metal-based electrode materials and proposed a new energy storage technology that combines supercapacitors with solar cells.

The paper is published in the journal Energy.

The research team designed the electrodes using a nickel-based carbonate and hydroxide composite material and maximized the conductivity and stability of the electrodes by adding transition metal ions such as Mn, Co, Cu, Fe, and Zn. This technology has greatly improved the performance of energy storage devices, demonstrating significant advancements in energy density, power density, and charge and discharge stability.

Particularly, the energy density achieved in this study is 35.5 Wh kg⁻¹, which is significantly higher than the energy storage per unit weight in previous studies (5-20 Wh kg⁻¹). The power density is 2555.6 W kg⁻¹, significantly exceeding the values from previous studies (- 1000 W kg⁻¹), demonstrating the ability to release higher power rapidly, enabling immediate energy supply even for high-power devices. Additionally, the performance showed minimal degradation during repeated charge and discharge cycles, confirming the long-term usability of the device.

Furthermore, the research team developed an energy storage device that combines silicon solar cells with supercapacitors, creating a system capable of storing solar energy and utilizing it in real time. This system achieved an energy storage efficiency of 63% and an overall efficiency of 5.17%, effectively validating the potential for commercializing the self-charging energy storage device.

Jeongmin Kim, Senior Researcher at the Nanotechnology Division of DGIST, states, "This study is a significant achievement, as it marks the development of Korea's first self-charging energy storage device combining supercapacitors with solar cells. By utilizing transition metal-based composite materials, we have overcome the limitations of energy storage devices and presented a sustainable energy solution."

Damin Lee, a researcher at the RLRC of Kyungpook National University, stated, "We will continue to conduct follow-up research to further improve the efficiency of the self-charging device and enhance its potential for commercialization."


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Drinking Half to One Glass of Wine Daily Linked to 50% Lower Heart Complication Risk

BY U. OF BARCELONA, DEC. 31, 2024


Moderate wine consumption, measured via biomarkers, is linked to a 38-50% reduction in cardiovascular risks, according to a University of Barcelona-led study. However, excessive drinking eliminates these benefits, and more research is needed to confirm causality and explore mechanisms.

Moderate wine consumption may lower cardiovascular risks by up to 50%, but more studies are needed to confirm these results and explore the underlying mechanisms.

Light to moderate wine consumption has been linked to a reduced risk of cardiovascular complications, according to a comprehensive multicenter study conducted by researchers from the University of Barcelona, Hospital Clínic, the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), the Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre (CIBEROBN), and the University of Navarra (UNAV).

Published in the European Heart Journal, the study examined the impact of wine intake using tartaric acid—a biomarker derived from grapes. The research involved 1,232 participants from the PREDIMED project, a large-scale epidemiological study focused on the Mediterranean diet’s effects on cardiovascular health.

According to the researchers, “there is no doubt that excessive alcohol consumption has serious health consequences. However, the effects of moderate and responsible wine consumption are still the subject of debate in the scientific community. The results of this study and others should help to place moderate wine consumption in its rightful place as an element of the Mediterranean diet, considered to be the healthiest in the world.”

While excessive alcohol consumption has serious health consequences, a new multicentre study provides new evidence that drinking between half a glass of wine and a full glass of wine a day could help reduce the risk of heart problems. 
Credit: European Heart Journal

The principal authors of the study are the researcher Inés Domínguez, from the UB’s Faculty of Pharmacy and Food Sciences and the Nutrition and Food Safety Research Institute (INSA); Professor Ramon Estruch, from the UB’s Faculty of Medicine and Health Sciences and IDIBAPS; Rosa María Lamuela, professor and ICREA Academia, and member of INSA, and Professor Miguel Ángel Martínez, from the University of Navarra (UNAV); all members of CIBEROBN.
​​​​​​​Controversy over the effects of wine

Today, there is much controversy about the health effects of moderate consumption of alcoholic beverages in general and wine in particular. Ramon Estruch stresses that “part of this debate is due to conflicting results of studies that have pointed to a protective effect of wine, while others have found no such effect.” These differences could be explained by possible errors in wine consumption records.

“Epidemiological studies assessing the role of wine in the rate of cardiovascular events are often based on self-reported information on wine consumption. These are reliable data, but subject to measurement errors due to inaccurate recall or biased perceptions about the social desirability of drinking alcoholic beverages,” he explains.

From left to right, the experts Rosa María Lamuela, Inés Domínguez, Ramon Estruch and Miguel Ángel Martínez. Credit: University of Barcelona

In response to this problem, the researchers in this study measured wine consumption by means of food intake frequency surveys, which they confirmed with an objective biomarker: the concentration found in the urine of tartaric acid, a molecule produced mainly in grapes and rarely synthesized by other plant species.

A reduction from 38% to 50%

Using this methodology, the study analyzed wine consumption and cardiovascular outcomes in a cohort of PREDIMED patients. In total, 1,232 participants were evaluated, including 685 who had a cardiovascular event (cardiovascular death, myocardial infarction, stroke, or heart failure) and 625 who were randomly selected.

Analysis of the data shows that light wine consumption (between one glass per week and less than half a glass per day) reduces the risk of having a cardiovascular complication by 38%, but this reduction reaches 50% when consumption is moderate (between half a glass and one glass per day).

However, when consumption exceeds one drink per day, the protective effect disappears. The researchers also warn that “when we talk about moderate wine consumption, it is always with meals, never between meals.”

More studies to confirm the results

Despite these conclusions, Inés Domínguez points out that “the observational design of the study limits the ability to establish causality,” and the experts point out that more research is needed: “The results of cohort studies should always be confirmed for greater certainty.”

In this regard, they point to two potential avenues for action. The first would involve the design of randomized nutritional intervention studies, by randomly assigning participants to groups with different wine consumption.

“These are very expensive studies to conduct. There is one underway now, but the results will still take four to five years,” they add. The second would be to study the mechanisms of these protective effects of wine on the cardiovascular system, such as research on the anti-inflammatory power of wine polyphenols — such as resveratrol and other phenolic compounds. “Knowing the mechanisms gives a lot of plausibility to the results of epidemiological cohort studies,” they conclude.​​​​


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Northern Lights Could Ring in New Year Following Massive Solar Eruptions

31 Dec. 2024, By M. STARR

Multiple flares recorded on the Sun. (NOAA)

As Earth completes yet another full orbit around the Sun, an encroaching storm is expected to bathe the planet in a glorious glow of auroral light.

On December 29 and 30 , the Sun unleashed a series of huge eruptions, flares, and coronal mass ejections, possibly right in our direction.

The flash of electromagnetic radiation caused brief radio blackouts on our planet's dayside just 8 minutes after leaving the Sun. But coronal mass ejections (CMEs) are huge eruptions of plasma that take hours to days to follow as they billow out through the Solar System.

On reaching us, CMEs slam into Earth's magnetic field, resulting in an event known as a geomagnetic storm – the most spectacular effect of which is the multi-hued aurorae that shimmer across the sky at high latitudes around the planet's poles.

A geomagnetic storm alert issued by the NOAA's Space Weather Prediction Center. 

The three eruptions in question took place over the course of 29 and 30 December 2024 UTC. On December 29, the Sun produced an X1.1 flare from sunspot region AR 3936. X-class flares are the most powerful class of flares. Then, on December 30, an X1.5 flare from the same region was followed by an X1.1 flare from sunspot region AR 3932.

Meanwhile, smaller flares popped up all over. There were 18 M-class flares – the second-most powerful category – counted on December 29 .

The CMEs are another matter. These are often released at the same time as flares, but the one that may be responsible for a geomagnetic storm on December 31 was recorded an hour prior to the first flare on December 29.

A second, smaller CME was recorded later the same day, with the possibility of a less powerful geomagnetic storm on January 1.

The NOAA has issued an alert for a powerful geomagnetic storm, but there are some caveats. Neither CME is expected to deliver a full frontal blow to Earth, which makes forecasting difficult.

And, as SpaceWeatherLive points out, based on the data we have, it's unclear whether the coronal mass ejections took place on the side of the Sun facing us at all. It's possible they erupted from the Sun's far side, in which case they're not headed our way at all.

Which, when you think about it, is perfect. What better way to end the year than a practical joke played by the Sun?


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Monday, 30 December 2024

Rewriting Archeological History: Early Near Eastern Architecture Was Far More Advanced Than We Thought

BY THE HEBREW U. OF JERUSALEM, DEC. 29, 2024

Aerial photograph of structures at the Natufian site of Nahal Ein Gev II, demonstrating the variety of shapes. 
Credit: Naftali Hilger

A computational analysis of early Near Eastern architecture reveals advanced building techniques and high variability in forms as early as the Natufian period, challenging traditional narratives.

A new study reveals that early architectural development in the Near East was more sophisticated than traditionally assumed, challenging the conventional narrative of a simple progression from round to rectangular structures during the Neolithic period.

By introducing a groundbreaking computational method to analyze architectural remains, the research offers an objective and repeatable way to examine building outlines. This approach uncovers details that qualitative methods might miss, such as the precise quantification of angles in structures dating back to the Natufian period, indicating that advanced building techniques emerged earlier than previously thought.


An aerial photograph of the Natufian site of Nahal Ein Gev II. 
Credit: Naftali Hilger



The study also highlights the architectural diversity during the Natufian and early Neolithic period, suggesting that building codes and more standard practices had not yet emerged. These findings provide new insights into the social and technological changes accompanying the rise of permanent settlements and agricultural economies.

Innovative Computational Methodology

A recent study led by researchers from the Institute of Archaeology at the Hebrew University—Hadas Goldgeier, Dr. Antoine Muller, and Prof. Leore Grosman—introduces a new computational method to analyze the architectural development of early settlements. By offering an objective and repeatable approach to examining architectural remains, the study gives a new perspective on the transition from round to rectangular structures during the Neolithic period in the Near East.

Architectural forms have long been tied to societal shifts such as changes in social organization, demographics, and economic strategies. However, traditional interpretations of early architecture have relied on qualitative methods, which may oversimplify complex trends.


Structure 6 at the Natufian site of Nahal Ein Gev II. 
Credit: Naftali Hilger



This study provides a fresh perspective by digitizing building outlines and employing computational tools to objectively quantify their two-dimensional morphology. Using measures like the directionality of normal vectors and minimum angles, the team analyzed 118 structures from 23 sites across the Mediterranean region and Jordan Valley, dating from the Natufian culture to the early Neolithic (15,000–8,500 years ago).
New Perspectives on Early Building Techniques

The results revealed a far more nuanced picture than the conventional “round-to-rectangular” narrative suggests. Structures with right angles, previously associated with later architectural phases, were found as early as the Natufian period, reflecting significant advances in building technology at an earlier stage than previously thought. Moreover, the variability in structure shapes was highest during the Natufian and early Neolithic periods, reflecting a lack of formalized conventions. Later in the Neolithic, however, architectural forms showed greater uniformity, potentially signaling the emergence of codified building traditions.

This study not only challenges traditional interpretations but also highlights the social and technological changes accompanying the transition to permanent settlements and agricultural economies. The computational methodology offers an innovative lens to understand architectural history, demonstrating how quantitative analyses can uncover trends that remain hidden in qualitative approaches.

By emphasizing the dynamic variability and technological ingenuity of early builders, this research sheds new light on the inception of architecture in the Levant and underscores the importance of integrating modern analytical tools into archaeological studies.


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Oleanolic acid from grapes may increase chemotherapy effectiveness

DEC. 30, 2024, by Sbarro Health Research Organization (SHRO)

OA reduces HeLa cell viability in combination with CPT. 
Credit: International Journal of Molecular Sciences (2024). DOI: 10.3390/ijms252413475

Researchers describe a new potential role for oleanic acid as a modulator of the DNA damage response following camptothecin treatment. Administration of oleanic acid in combination with camptothecin for cancer chemotherapy may reduce the amount of drug needed and increase the effectiveness of treatment. The findings are part of a novel research program focused on identifying new molecules for cancer therapy derived from natural extracts.

The study, titled "Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death," was published last week in the International Journal of Molecular Sciences.

The research group is led by Prof. Antonio Giordano, M.D., Ph.D., Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, Professor of Pathology at the University of Siena, and Founder of the Sbarro Health Research Organization (SHRO), along with Dr. Luigi Alfano from the Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy.

Researchers working with SHRO and Giordano have been responsible for numerous groundbreaking discoveries in molecular biology and precision medicine, including capsaicin's potential to enhance mesothelioma treatment, a study about the role of CDK9 in oncology, and a genetic target to reduce blood vessel growth in glioblastoma tumors.

In this new study, oleanic acid was identified in a grape pomace extract using Nuclear Magnetic Resonance (NMR), revealing a significant effect on the viability of cancer cell lines when combined with a chemotherapeutic drug. The addition of oleanic acid acts as an additive compound with camptothecin, reducing the required concentration of the chemotherapeutic drug compared to camptothecin alone. Moreover, oleanic acid does not affect cell viability at the concentrations used in these experiments.

"This is an important discovery for our group, highlighting the potential of natural extracts as a source of molecules for cancer therapy," says Alfano.

"Use of oleanic acid may allow us to reduce the camptothecin drug concentration needed to get the desired anti-cancer result," says senior author Giordano. "Lower doses of chemotherapy suggest the possibility of reducing the side effects associated with cancer treatment, making the experience more tolerable for patients."


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Simple Dietary Supplement Could Supercharge Cancer-Fighting Immune Cells

BY U. OF PENNSYLVANIA SCHOOL OF MEDICINE, DECEMBER 29, 2024


Researchers at Penn Medicine discovered that a ketogenic diet or BHB supplements may boost CAR T cell therapy’s effectiveness in fighting cancer by enhancing T cell metabolism. While promising early results have led to a Phase I clinical trial, further evidence is needed before dietary recommendations can be made.

Laboratory studies uncover a simple yet promising approach to enhance personalized cell therapy.

A dietary supplement may offer a novel way to enhance the effectiveness of CAR T cell therapy, according to a study conducted by researchers at the Perelman School of Medicine and the Abramson Cancer Center at the University of Pennsylvania. Although this method requires validation through clinical trials, early findings—recently presented during a press briefing at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition—suggest a potentially affordable and accessible strategy to improve CAR T cell functionality and cancer-fighting capabilities.

CAR T cell therapy, first developed at Penn Medicine, is a personalized cancer treatment that reprograms a patient’s immune cells to target and destroy cancer cells.

“Thousands of patients with blood cancers have been successfully treated with CAR T cell therapy, but it still doesn’t work for everyone,” said co-lead author Shan Liu, PhD, a postdoctoral fellow who presented the study at ASH. “We took an outside-the-box approach to improve CAR T cell therapy, by targeting T cells through diet rather than further genetic engineering.”

Liu co-led the study with Puneeth Guruprasad, PhD, who earned his PhD at Penn and is now a medical student in the Perelman School of Medicine. The lead authors worked under the mentorship of co-senior authors Marco Ruella, MD, an assistant professor of Hematology-Oncology, a researcher with the Center for Cellular Immunotherapies and the scientific director of Penn Medicine’s Lymphoma Program; and Maayan Levy, PhD, an assistant professor of Microbiology.
CAR T cells prefer BHB as a fuel source

First, the research team tested the effect of several different diets, including ketogenic, high-fiber, high-fat, high-protein, high cholesterol, and a control diet, on CAR T cell’s tumor-fighting capabilities using a mouse model of diffuse-large B-cell lymphoma. They found improved tumor control and survival in the mice receiving a ketogenic diet compared to all other diets. In subsequent studies, they found higher levels of beta-hydroxybutyrate (BHB), a metabolite produced by the liver in response to a ketogenic diet, was a key mediator of this effect.

The research builds on previous work from Levy’s team, which found that BHB strongly suppressed the growth of colorectal tumors in lab experiments.

“Our theory is that CAR T cells prefer BHB as a fuel source rather than standard sugars in our body, such as glucose,” Guruprasad said. “So, increasing the levels of BHB in the body gives the CAR T cells more power to take out the cancer cells.”
Translational studies in patient samples and healthy volunteers

Next, the research team tested a BHB supplement combined with CAR T cell therapy in laboratory models of human cancer (on a standard diet); the results showed complete obliteration of the cancer in the vast majority of mice and resulted in higher CAR T cell expansion and activation. To see if BHB, which occurs naturally at various levels in our bodies, had a similar effect in humans, the team assessed blood samples from patients who had recently received CAR T cell therapy and found that greater BHB levels were associated with better CAR T cell expansion in patients. They also looked at T cells of healthy volunteers who took a BHB supplement and found similar changes in how normal T cells generated energy after exposure to BHB.

Past studies across several cancer types have looked at the impact of dietary interventions, such as a high-fiber diet, on the response to cancer immunotherapy, however, the mechanism behind the BHB effect in this study appears to stem from metabolic changes in the blood, rather than via the gut microbiome, as in the case of a high-fiber diet.
Next steps and potential impact

The theory that BHB supplementation could improve response to CAR T cell therapy is being tested in a Phase I clinical trial at Penn Medicine’s Abramson Cancer Center.

“We’re talking about an intervention that is relatively cheap and has low toxicity potential,” Levy said. “If the clinical trial data pans out, I’m excited to think about how a fairly simple approach like this could be combined with dietary interventions or other, more traditional approaches, to enhance the anti-cancer effect.”

The clinical trial, led by principal investigator Elise Chong, MD, an assistant professor of Hematology-Oncology, will soon begin enrolling patients with relapsed or refractory large B-cell lymphoma who are receiving commercially available anti-CD19 CAR T cell therapy as part of their treatment.

“As a physician and scientist, I share my patients’ excitement for potential new strategies to better treat their cancer, and I’m thrilled to see this research move from the lab bench to translational studies and now to a clinical trial,” Ruella said. “However, we want to emphasize that, at this point, the research is still preliminary, and we’re not making any dietary or supplement recommendations to patients based on this study until we have definitive clinical evidence.”

Meeting: 66th American Society of Hematology (ASH) Annual Meeting and Exposition

The study was partly funded by the Penn-CHOP Microbiome Core.

Patients interested in clinical trials at the Abramson Cancer Center can search open clinical trials here or call 1-855-216-0098 to speak with a clinical trial naviga


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Sunday, 29 December 2024

The Dark Side of Electric Vehicles: A Hidden Pollution Problem

BY PRINCETON U., DEC. 29, 2024

Electric vehicles are essential to the global energy transition, but new research reveals that refining minerals like nickel and cobalt for EV batteries could create significant pollution hotspots. The study, focused on China and India, found that domesticating EV supply chains could raise sulfur dioxide (SO2) emissions by up to 20%, underscoring the importance of clean supply chain strategies. 
Credit: Bumper DeJesus, Princeton University

EV battery production could increase SO2 pollution, with China and India facing distinct challenges. Clean supply chains, strict pollution standards, and alternative battery chemistries like lithium iron phosphate are essential to mitigating these effects while advancing decarbonization.

Electric vehicles are a key component of the global shift toward sustainable energy, but a new study from Princeton University highlights a significant challenge: the refining of critical minerals for EV batteries could lead to pollution hotspots near manufacturing centers.

The study focused on China and India, revealing that fully domesticating their supply chains for EV production could drive national sulfur dioxide (SO2) emissions up by as much as 20% compared to current levels. Most of these emissions would stem from the refining and production of nickel and cobalt, essential materials for modern electric vehicle batteries.

“Many discussions about electric vehicles focus on minimizing emissions from the transport and power sectors,” said corresponding author Wei Peng, an assistant professor of public and international affairs and the Andlinger Center for Energy and the Environment. “But we show here that the impacts of electric vehicles don’t end with vehicle tail-pipe emissions or electricity. It’s also about your entire supply chain.”

Publishing their findings in Environmental Science & Technology, the researchers argued that countries must think strategically about building clean supply chains as they develop decarbonization plans.

In the case of battery manufacturing, the team underscored the importance of developing and enforcing strict air pollution standards to avoid unintended consequences of the transition to electric vehicles. They also suggested the development of alternative battery chemistries to avoid the process-based SO2 emissions of manufacturing today’s batteries.

“If you dig deep enough into any clean energy technology, you will find there are challenges or tradeoffs,” said first author Anjali Sharma, who completed the work as a postdoctoral researcher in Peng’s group and is now an assistant professor in the Centre for Climate Studies and Ashank Desai Centre for Policy Studies at the Indian Institute of Technology, Bombay. “The existence of these tradeoffs doesn’t mean that we stop the energy transition, but it does mean that we need to act proactively to mitigate these tradeoffs as much as possible.”

A tale of two countries

Both China and India have good reasons to avoid SO2 emissions: the compound is a precursor to fine particulate matter, contributing to a host of cardiovascular and respiratory problems. The two countries already suffer from high levels of air pollution. In 2019 alone, around 1.4 million premature deaths in China and around 1.7 million premature deaths in India were attributable to fine particulate matter exposure.

However, the two countries are at different stages of development for electric vehicles. Peng said that in China, a domestic supply chain for electric vehicles is the status quo, but that India is still in the early stages of supply chain development. The comparison helped the researchers identify near-term priorities as they continue or begin to build a domestic supply chain for electric vehicles.

“China needs to be thinking about how to clean up a supply chain that already exists, while India has the opportunity to build a better supply chain from the ground up,” said Peng, who is also a core faculty at the Center for Policy Research on Energy and the Environment. “Both situations come with their own challenges and opportunities.”

In India, the lowest-hanging fruit would be to focus first on cleaning up pollution from the power sector. This would require enforcing stringent SO2 pollution control measures for thermal power plants, using mature technologies like flue-gas desulfurization. For China, which already has stringent emissions controls for the power sector, the focus needs to shift to mitigating SO2 emissions from the battery manufacturing process, which the researchers said is less familiar.

However, the researchers underscored that ignoring emissions from battery manufacturing would be a critical misstep. In scenarios where China and India fully onshored their supply chains, prioritizing a cleaner grid did little to nothing to lower SO2 emissions. Instead, only scenarios focused on cleaning up battery manufacturing processes avoided SO2 pollution hotspots.

“People generally assume the transition to a greener technology is always going to be a win-win — there will be climate and air quality benefits,” said Sharma. “But without considering manufacturing, you might lower carbon and nitrogen oxide emissions but end up increasing the air pollution burden for communities near manufacturing centers.”

Human-centered approaches to decarbonization

While the analysis focused on China and India, the researchers argued that if left unaddressed, pollution from battery manufacturing will become an increasingly global challenge as electric vehicle adoption rates rise. Even if countries like China and India were to outsource battery manufacturing, Sharma said that without strategies to mitigate SO2 emissions, they would simply be offloading the problem to another country.

“It’s important to look at electric vehicles from a global supply chain perspective,” Sharma said. “Even if India were to decide against building a domestic supply chain and instead chose to import them from somewhere else, the pollution wouldn’t go away. It would just be outsourced to another country.”

In addition to their policy recommendation for proactive air pollution standards, which would likely happen at the national or subnational level, the researchers also examined how changing the battery chemistry in electric vehicles could avoid unwanted SO2 emissions at a more global scale.

While most electric vehicle batteries today rely on cobalt and nickel, the rise of alternative chemistries that use iron and phosphate (so-called lithium iron phosphate batteries) could circumvent some of the concerns associated with mining and refining cobalt and nickel. By avoiding the two minerals, scenarios with high penetration of lithium phosphate batteries resulted in far fewer SO2 emissions from manufacturing.

In all events, Peng said the findings serve as a reminder to keep people at the top of mind when designing decarbonization plans, as even the most promising technologies could come with unwanted and unintended consequences.

“We know about many of the important technologies for cutting carbon emissions,” said Peng. “But the other part is how people will be affected by those technologies. My approach is to think about the best ways for technologies and people to intersect, because those strategies will have the best outcomes for the greatest number of people.”

In addition to Peng and Sharma, authors include Johannes Urpelainen of Johns Hopkins University, Hancheng Dai of Peking University, and Pallav Purohit and Fabian Wagner of the International Institute for Applied Systems Analysis (IIASA). The work was supported by the Wellcome Trust Climate Change and Health Award, as well as Princeton’s School of Public and International Affairs.


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Norovirus cases surge in US, causing widespread stomach illness

DEC. 29, 2024, by A. Snow


This electron microscope image provided by the Centers for Disease Control and Prevention shows a cluster of norovirus virions. 
Credit: Charles D. Humphrey/CDC via AP, File



Cases of a wretched stomach bug are surging in parts of the United States this winter, according to government data.

The most recent numbers from the U.S. Centers for Disease Control and Prevention show there were 91 outbreaks of norovirus reported during the week of Dec. 5, up from 69 outbreaks the last week of November.

Numbers from the past few years show a maximum of 65 outbreaks reported during that first week of December.

A norovirus infection is characterized by sudden vomiting and diarrhea. Outbreaks are often seen on cruise ships, in congregate living situations like nursing homes and jails, as well as schools and places where people are close together.

Here are a few things to know about the virus.

What is norovirus?

Norovirus is the leading cause of foodborne illness in the United States, responsible for 58% of such infections acquired in the country each year, according to the CDC.

Norovirus infections are caused by a group of viruses that spread easily, with as few as 10 viral particles having the ability to make someone sick, health experts say.

There are about 2,500 norovirus outbreaks reported annually in the United States. The outbreaks can occur throughout the year but are most common from November to April.

Along with with vomiting and diarrhea, common symptoms include nausea, stomach pain, body ache, headache and fever.

How do you get it?

Most norovirus outbreaks occur when people who are already infected spread the virus to others by direct means, such as through sharing food or eating utensils. Outbreaks can also be spread through food, water or contaminated surfaces .

How long do you stay sick?

Illness caused by norovirus typically starts suddenly, with symptoms developing 12 to 48 hours following exposure to the virus. Most people get better within one to three days and recover fully.

But with 19 to 21 million illnesses each year in the United States, norovirus nevertheless causes on average 900 deaths and 109,000 hospitalizations annually, mostly among adults aged 65 and older. It also leads to 465,000 emergency department visits, mostly involving young children.

Who's at risk?

People of all ages can get infected and fall sick from norovirus. Young children, older people and those with weakened immune systems are most at risk, with dehydration from vomiting and diarrhea the top concern.

There is no medication to treat norovirus. Rehydration is recommended by drinking water and other liquids, with the exception of coffee, tea and alcohol.

Anyone suffering from dehydration should seek medical help. Symptoms of dehydration include a decrease in urination, dry mouth and throat, and feeling dizzy when standing. Dehydrated children may be unusually sleepy or fussy and cry with few or no tears.

How can I protect myself?

Rigorous and frequent handwashing is the best defense against norovirus during the peak winter season, scrubbing the hands with soap and warm water for 20 seconds before meals.

Scrubbing surfaces with household disinfectants can also help.


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NASA Is Watching a Vast, Growing Anomaly in Earth's Magnetic Field

29 Dec. 2024, By P. DOCKRILL

The South Atlantic Anomaly. (NASA Goddard/YouTube)

NASA has been monitoring a strange anomaly in Earth's magnetic field: a giant region of lower magnetic intensity in the skies above the planet, stretching out between South America and southwest Africa.

This vast, developing phenomenon, called the South Atlantic Anomaly, has intrigued and concerned scientists for years, and perhaps none more so than NASA researchers.

The space agency's satellites and spacecraft are particularly vulnerable to the weakened magnetic field strength within the anomaly, and the resulting exposure to charged particles from the Sun.

The South Atlantic Anomaly (SAA) – likened by NASA to a 'dent' in Earth's magnetic field, or a kind of 'pothole in space' – generally doesn't affect life on Earth, but the same can't be said for orbital spacecraft (including the International Space Station), which pass directly through the anomaly as they loop around the planet at low-Earth orbit altitudes.

During these encounters, the reduced magnetic field strength inside the anomaly means technological systems onboard satellites can short-circuit and malfunction if they become struck by high-energy protons emanating from the Sun.

https://www.youtube.com/watch?v=qpdQcw_52iM&t=1s

These random hits may usually only produce low-level glitches, but they do carry the risk of causing significant data loss, or even permanent damage to key components – threats obliging satellite operators to routinely shut down spacecraft systems before spacecraft enter the anomaly zone.

Mitigating those hazards in space is one reason NASA is tracking the SAA; another is that the mystery of the anomaly represents a great opportunity to investigate a complex and difficult-to-understand phenomenon, and NASA's broad resources and research groups are uniquely well-appointed to study the occurrence.

"The magnetic field is actually a superposition of fields from many current sources," geophysicist Terry Sabaka from NASA's Goddard Space Flight Centre in Greenbelt, Maryland explained in 2020.

The primary source is considered to be a swirling ocean of molten iron inside Earth's outer core, thousands of kilometers below the ground. The movement of that mass generates electrical currents that create Earth's magnetic field, but not necessarily uniformly, it seems.

A huge reservoir of dense rock called the African Large Low Shear Velocity Province, located about 2,900 kilometers (1,800 miles) below the African continent, is thought to disturb the field's generation, resulting in the dramatic weakening effect – which is aided by the tilt of the planet's magnetic axis.

"The observed SAA can be also interpreted as a consequence of weakening dominance of the dipole field in the region," said NASA Goddard geophysicist and mathematician Weijia Kuang in 2020.

"More specifically, a localized field with reversed polarity grows strongly in the SAA region, thus making the field intensity very weak, weaker than that of the surrounding regions."

Satellite data suggesting the SAA is dividing. 
(Division of Geomagnetism, DTU Space)

While there's much scientists still don't fully understand about the anomaly and its implications, new insights are continually shedding light on this strange phenomenon.

For example, one study led by NASA heliophysicist Ashley Greeley in 2016 revealed the SAA slowly drifts around, which was confirmed by subsequent tracking from CubeSats in research published in 2021.

It's not just moving, however. Even more remarkably, the phenomenon seems to be in the process of splitting in two, with researchers in 2020 discovering that the SAA appeared to be dividing into two distinct cells, each representing a separate center of minimum magnetic intensity within the greater anomaly.

Just what that means for the future of the SAA remains unknown, but in any case, there's evidence to suggest that the anomaly is not a new appearance.

A study published in July 2020 suggested the phenomenon is not a freak event of recent times, but a recurrent magnetic event that may have affected Earth since as far back as 11 million years ago.

If so, that could signal that the South Atlantic Anomaly is not a trigger or precursor to the entire planet's magnetic field flipping, which is something that actually happens, if not for hundreds of thousands of years at a time.

A more recent study published this year found the SAA also has an impact on auroras seen on Earth.

Obviously, huge questions remain, but with so much going on with this vast magnetic oddity, it's good to know the world's most powerful space agency is watching it as closely as they are.

"Even though the SAA is slow-moving, it is going through some change in morphology, so it's also important that we keep observing it by having continued missions," said Sabaka.


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Saturday, 28 December 2024

Japanese Scientists Unveil Game-Changing 3D Printing Breakthrough for Lightweight Cars

BY TOHOKU U., DEC. 26, 2024

Researchers at Tohoku University have developed a groundbreaking multi-material 3D printing technique using Laser Powder Bed Fusion (L-PBF) to create lightweight yet durable automotive components. By increasing laser scan speed, they suppressed brittle intermetallic compounds in steel-aluminum alloys, enabling the successful production of the world’s first 3D-printed full-scale suspension tower. 
(Artist’s concept.)

Tohoku University developed a durable steel-aluminum alloy via 3D printing, overcoming brittleness challenges with advanced laser techniques, paving the way for innovative, lightweight automotive components.

Researchers at Tohoku University’s Institute for Materials Research and New Industry Creation Hatchery Center have achieved a significant breakthrough in multi-material 3D printing, showcasing its potential for manufacturing lightweight yet durable automobile components.

Metal 3D printing involves building objects layer by layer, binding metal layers together using heat. This technique offers remarkable precision, enabling the creation of unique, highly customizable shapes while minimizing material waste compared to traditional manufacturing processes.


A key advantage of 3D printing is the ability to produce “multi-material structures,” which combine different materials strategically to optimize a component’s performance. For instance, integrating aluminum with steel in automobile parts can significantly reduce weight while maintaining strength. These advantages have made advanced 3D printing techniques a focal point for researchers worldwide, as they hold great promise for innovation in manufacturing.

Steel/Al alloy interfaces obtained using L-PBF at different scan speeds. Credit: ©Kenta Yamanaka et al.However, this technique does come with some challenges.”Multi-materials are a hot topic in the field of additive manufacturing due to its process flexibility,” explains Associate Professor Kenta Yamanaka (Tohoku University), “However, a major challenge in practical implementation is that for certain metal combinations, such as steel and aluminum, brittle intermetallic compounds can be formed at the dissimilar metal interfaces. So, while the material is now lighter, it ends up being more brittle.”


Full-scale prototype of a topologically optimized automotive suspension tower manufactured via L-PBF. 
Credit: ©Kenta Yamanaka et al.



Overcoming Challenges: Laser Powder Bed Fusion (L-PBF)

The goal of this study was to produce a steel-aluminum alloy that was lightweight but did not compromise on strength. To do so, the research team used Laser Powder Bed Fusion (L-PBF), one of the primary metal 3D printing technologies that employs a laser to selectively melt metal powders.

They discovered that increasing the scan speed of the laser significantly suppresses the formation of brittle intermetallic compounds (such as Al5Fe2 and Al13Fe4). They proposed that this higher scanning speed leads to something called non-equilibrium solidification, which minimizes solute partitioning that result in weak points in the material. The resulting product they created consequently demonstrated strong bonding interfaces.


Interfacial strength for steel/Al alloy multi-materials obtained using L-PBF at different scan speeds. 
Credit: ©Kenta Yamanaka et al.



“In other words, you can’t just slap two metals together and expect them to stick without a plan,” says Specially Appointed Assistant Professor Seungkyun Yim (Tohoku University),”We had to fully understand the in-situ alloying mechanism first.”

Based on this achievement, they successfully prototyped the world’s first full-scale automotive multi-material component (suspension tower) with a tailored geometry. The research group intends to apply these findings to other metal combinations where similar issues with bonding need improvement, which will allow for more broad applications.


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A new structure design enables a dual-function system for infrared camouflage and thermal management

DEC. 27, 2024, by National Taiwan U.

Epsilon-near-zero (ENZ) thin films stack on a metal-based bottom layer within a dual-functional system for thermal infrared camouflage and thermal management within the atmospheric window. 
Credit: National Taiwan University

Combining metallic glass with the Berreman mode of epsilon-near-zero (ENZ) thin films achieves a dual-function system for infrared camouflage and thermal management within an identical wavelength region of the atmospheric window. In recent research, metallic glasses were selected for their tunable optical properties, providing adjustable emissivity for versatile thermal camouflage while maintaining effective thermal management.

Thermal infrared camouflage aims to reduce the detectability of a target using thermal imaging devices. Given the typically high thermal emissivity in everyday environments, the thermal emissivity of the background environment must be considered. The conventional low-emissivity strategy for thermal camouflage is only effective for targets at extremely high temperatures, making it unsuitable for applications near room-to-medium-high temperature range (<350 °C).

In a study published in Materials Horizons, Professor Hsuen-Li Chen from the Department of Materials Science and Engineering at National Taiwan University led his research team in designing an innovative multilayer thin-film structure. This structure introduces metallic glass into infrared thermal camouflage technology, exploiting its adjustable emissivity to accommodate diverse infrared thermal camouflage scenarios.

Moreover, this is the first time combining metallic glass with the Berreman mode of epsilon-near-zero (ENZ) thin films.

In the long wave infrared (LWIR, 8–14 μm) regions, the small viewing angle exhibited the optical properties of metallic glasses. As the viewing angle increased, driven by the multiple Berreman modes of the ENZ thin films, it provided high thermal emissivity in transverse-magnetic (TM) polarization. It enabled thermal management without compromising the thermal camouflage performance.

The cooling power exhibited by ENZ thin films on metallic glass surpassed that of the conventional low-emissivity strategy for thermal camouflage by a factor of 1.79. Furthermore, the thermal images indicated over 97% similarity in thermal radiation between the target and background environments.

This presents new avenues for advancing infrared thermal camouflage technology.


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Why Are Bed Bugs So Hard To Kill? Scientists Uncover Genetic Survival Secrets

BY HIROSHIMA U. DEC.  28, 2024


Scientists sequenced near-complete genomes of susceptible and highly insecticide-resistant bed bug strains, uncovering 729 resistance-specific mutations, including genes linked to DNA damage response and cell cycle regulation. These findings could guide more effective pest control strategies and shed light on the evolution of resistance mechanisms.

Scientists have successfully mapped near-complete and highly accurate genomes for two strains of bed bugs: one highly susceptible to insecticides and another “superstrain” that is roughly 20,000 times more resistant. This achievement provides the most comprehensive view yet of the genetic mutations behind insecticide resistance. The findings were published in the journal Insects.

While bed bugs are not known to transmit diseases to humans, their bites can cause itchy rashes and secondary infections. Insecticide use, including the now-banned DDT, nearly eradicated bed bug populations by the 1960s, making infestations a rarity. However, over the past two decades, bed bugs have made a global resurgence, largely due to genetic mutations that have rendered them resistant to modern insecticides.

Resistance can develop through various mechanisms, such as producing detoxifying enzymes (metabolic resistance) or evolving thicker protective outer layers that block chemicals (penetration resistance). Previous studies have identified some of the genes and mutations involved in resistance, but the complete genetic picture remained unclear because no prior research had sequenced the entire genomes of resistant strains. This new study fills critical gaps, shedding light on the full spectrum of mutations driving their resilience.

The number of mutation sites per transcript is shown by circles. (b–g) Mutation sites of candidate resistance genes are shown with different amino acids. “Susceptible” refers to the susceptible strain sequenced in this study and Clec2.1 (pre-existing genome sequence of bed bugs). Gene IDs are indicated by ‘g’ followed by a number, and transcript variations are denoted by ‘t’ followed by a number. In (b), two mutated sites corresponded to the sites of 925 in housefly Musca domestica. 
Credit: Kouhei Toga/Hiroshima University

A research team led by Hidemasa Bono, professor at Hiroshima University’s (HU) Graduate School of Integrated Sciences for Life, mapped genomes of susceptible and resistant bed bug strains from Japan to address this gap. They obtained susceptible strains descended from wild bed bugs (Cimex lectularius) collected 68 years ago in fields at Isahaya City, Nagasaki. Meanwhile, the resistant strains were bred from specimens collected from a Hiroshima City hotel in 2010. Their tests revealed that the resistant samples had 19,859-fold stronger resistance to pyrethroids — the most commonly used insecticide for bed bug control — exceeding levels seen in many previously identified superstrains. All the specimens were provided by Fumakilla Limited, a Japan-based chemical manufacturing company.

Piecing together the genome puzzle

Sequencing a genome is like assembling a massive jigsaw puzzle, spanning anywhere from about 160,000 to 160 billion pieces. To map the most complete bed bug genomes to date, researchers used the breakthrough method of long-read sequencing, which captures longer stretches of DNA—akin to having entire sections of puzzle pieces put together. Traditional short-read sequencing, by contrast, only covers tiny snippets, often leading to frustrating gaps.

The researchers assembled a near-total picture of the two genomes with just about every piece precisely where it belonged, achieving 97.8% completeness and quality value (QV) of 57.0 for the susceptible strain and 94.9% completeness and QV of 56.9 for the resistant strain. A QV above 30 indicates high-quality sequences with less than 0.1% error rate. Both also surpassed the N50 value of the existing C. lectularius reference genome, Clec2.1, from a previous sequencing effort, meaning there were fewer gaps and more complete sections of the genome puzzle.

Known, new resistance mutations uncovered

After fully sequencing the genomes, the team identified protein-coding genes, determined their functions, and assessed if they were active through transcriptional analysis. They uncovered 3,938 transcripts with amino acid mismatches. Of these, 729 mutated transcripts were linked to insecticide resistance.

“We determined the genome sequence of insecticide-resistant bed bugs, which exhibited 20,000-fold greater resistance compared to susceptible bed bugs. By comparing the amino acid sequences between the susceptible and resistant bed bugs, we identified 729 transcripts with resistance-specific mutations,” said study first author Kouhei Toga, postdoctoral researcher at the Laboratory of Genome Informatics of HU’s Graduate School of Integrated Sciences for Life.

“These transcripts included genes related to DNA damage response, cell cycle regulation, insulin metabolism, and lysosome functions. This suggests that these molecular pathways may play a role in the development of pyrethroid resistance in bed bugs.”

By drawing on previous insect studies, the researchers confirmed known resistance mutations and discovered new ones that could inform more targeted and effective pest control strategies.

“We identified a large number of genes likely involved in insecticide resistance, many of which have not been previously reported as being associated with resistance in bedbugs. Genome editing of these genes could provide valuable insights into the evolution and mechanisms of insecticide resistance,” Toga said.

“Additionally, this study expands the pool of target genes for monitoring allele distribution and frequency changes, which could contribute significantly to assessing resistance levels in wild populations. This work highlights the potential of genome-wide approaches in understanding insecticide resistance in bed bugs.”

The study was funded by the Japan Science and Technology Agency and the Subsidy for Bioeconomy Industry Creation Support Project (Hiroshima Prefecture).

Other research team members include Fumiko Kimoto and Hiroki Fujii, who are employees of Fumakilla Limited.


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Friday, 27 December 2024

Food recall update: Сlass 1 alert issued for Costco eggs linked to salmonella

DEC. 26, 2024, by I. Edwards

The U.S. Food and Drug Administration (FDA) has escalated the recall of certain eggs sold at Costco to its highest Class 1 alert level due to salmonella contamination risks.

According to the FDA, The Handsome Brook Farms Kirkland Signature Organic Pasture Raised 24-Count Eggs were distributed to Costco locations in Tennessee, Alabama, Georgia, North Carolina, and South Carolina.

The FDA's Class 1 designation signifies a "reasonable probability" that consuming the eggs could cause "serious adverse health consequences or death," the news release shows.

Approximately 10,800 retail units of the eggs were distributed to 25 Costco stores starting Nov. 22, but the recall was initially issued on Nov. 27 after the company found that eggs not intended for retail sale were packaged and shipped in retail cartons.

Handsome Brook Farms emphasized in its initial announcement that "additional supply chain controls and retraining are being put in place to prevent recurrence."

The affected egg cartons have a Universal Product Code (UPC) of 9661910680 and a use-by date of Jan. 5, 2025.

Consumers should immediately return the eggs to Costco for a full refund or dispose of them, the FDA said.

The Centers for Disease Control and Prevention (CDC) cautions that salmonella infections can cause severe stomach cramps, nausea, diarrhea, vomiting, headaches, and loss of appetite.

Symptoms typically appear six hours to six days after infection and can last up to a week.

Certain groups, including children under 5, adults over 65, and individuals with weakened immune systems, may face more severe illnesses requiring medical care or hospitalization.


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